SCHEMBL3728817 — predicted protein targets

Predicted protein targets (top 17)

	gene	UniProt	supporting neighbours	confidence
▸	TDP1	Q9NUW8	12/20	0.60

▸	JAK2	O60674	4/20	0.49

▸	JAK1	P23458	4/20	0.49

▸	JAK3	P52333	4/20	0.49

▸	TYK2	P29597	3/20	0.49

▸	BRD4	O60885	1/20	0.41

▸	TDP2	O95551	1/20	0.37

▸	NUAK1	O60285	1/20	0.37

▸	NTRK1	P04629	1/20	0.37

▸	FLT3	P36888	1/20	0.37

▸	NUAK2	Q9H093	1/20	0.37

▸	BMP2K	Q9NSY1	1/20	0.37

▸	USP2	O75604	1/20	0.37

▸	MEN1	O00255	1/20	0.37

▸	MAPK1	P28482	1/20	0.37

▸	KMT2A	Q03164	1/20	0.37

▸	TOP1	P11387	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL3721877	0.92	TDP1 (0.61)	TDP1JAK2JAK1JAK3TYK2
SCHEMBL29360706	0.92	TDP1 (0.69)	TDP1JAK2JAK1JAK3TYK2
SCHEMBL241242	0.92	TDP1 (0.69)	TDP1JAK2JAK1JAK3TYK2
SCHEMBL12457216	0.91	TDP1 (0.51)	TDP1JAK2JAK1JAK3TYK2
SCHEMBL3721281	0.90	TDP1 (0.57)	TDP1JAK2JAK1JAK3TYK2
SCHEMBL3720038	0.90	TDP1 (0.59)	TDP1JAK2JAK1JAK3TYK2
SCHEMBL3722720	0.90	TDP1 (0.58)	TDP1JAK2JAK1JAK3TYK2
SCHEMBL19456979	0.89	TDP1 (0.56)	TDP1JAK2JAK1JAK3TYK2
SCHEMBL3721285	0.89	TDP1 (0.57)	TDP1JAK2JAK1JAK3TYK2
SCHEMBL3722560	0.88	TDP1 (0.58)	TDP1JAK2JAK1JAK3TYK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-9321781-B2	Topoisomerase inhibitors	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US)	2016-04-26	—	—	US	claimed
US-20120237531-A1	TOPOISOMERASE INHIBITORS	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	2012-09-20	—	—	US	claimed
WO-2010127363-A1	TOPOSIOMERASE INHIBITORS	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US)	2010-11-04	—	—	WO	claimed
WO-2010127360-A1	TOPOSIOMERASE INHIBITORS	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US)	2010-11-04	—	—	WO	claimed
US-9321781-B2	Topoisomerase inhibitors	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US)	2016-04-26	—	—	US	disclosed
US-9321781-B2	Topoisomerase inhibitors	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US)	2016-04-26	—	—	US	disclosed
US-20120237531-A1	TOPOISOMERASE INHIBITORS	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	2012-09-20	—	—	US	disclosed
US-20120237531-A1	TOPOISOMERASE INHIBITORS	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	2012-09-20	—	—	US	disclosed
WO-2010127363-A1	TOPOSIOMERASE INHIBITORS	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US)	2010-11-04	—	—	WO	disclosed
WO-2010127360-A1	TOPOSIOMERASE INHIBITORS	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US)	2010-11-04	—	—	WO	disclosed
WO-2010127363-A1	TOPOSIOMERASE INHIBITORS	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US)	2010-11-04	—	—	WO	disclosed
WO-2010127360-A1	TOPOSIOMERASE INHIBITORS	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US)	2010-11-04	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20120237531-A1	TOPOISOMERASE INHIBITORS	TOP1, TOP2A, TOP2B	TDP1 10/4885JAK2 1816/4885JAK1 2024/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.