Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.61 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078372 | 0.84 | BTK (0.73) | BTKCLK2KDM4ERAB9ASRC | |
| SCHEMBL12602983 | 0.82 | BTK (0.75) | BTKCLK2KDM4ERAB9ASRC | |
| SCHEMBL3963393 | 0.81 | BTK (0.71) | BTKCLK2KDM4ERAB9A | |
| SCHEMBL1726747 | 0.81 | BTK (0.63) | BTKCLK2KDM4ERAB9ASRC | |
| SCHEMBL171985 | 0.79 | BTK (0.70) | BTKCLK2KDM4ERAB9A | |
| SCHEMBL12650372 | 0.78 | BTK (0.70) | BTKCLK2KDM4ERAB9ASRC | |
| SCHEMBL13894070 | 0.78 | BTK (0.88) | BTKCLK2 | |
| SCHEMBL3867754 | 0.77 | BTK (0.74) | BTKCLK2KDM4ERAB9ASRC | |
| SCHEMBL1725678 | 0.77 | BTK (0.70) | BTKCLK2KDM4ERAB9A | |
| SCHEMBL5127683 | 0.76 | BTK (0.62) | BTKCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242749-B1 | NOVEL PYRIDINONES AND PYRIDAZINONES | HOFFMANN LA ROCHE (CH) | 2013-04-10 | — | — | EP | disclosed |
| EP-2242749-A1 | NOVEL PYRIDINONES AND PYRIDAZINONES | F. Hoffmann-La Roche AG (CH) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009098144-A1 | NOVEL PYRIDINONES AND PYRIDAZINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-13 | — | — | WO | disclosed |