Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.32 |
| ▸ | GABRD | O14764 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.32 |
| ▸ | GABRE | P78334 | 2/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.32 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL8946606 | 0.87 | ALDH1A1 (0.39) | PTGS1ALDH1A1TSHRGLAL3MBTL1 | |
| Propylene Glycol SCHEMBL445126 | 0.84 | FFAR3 (0.46) | TDP1ALDH1A1TSHRGABRPGABRD | |
| SCHEMBL3726871 | 0.84 | TDP1 (0.43) | TDP1HSD17B10 | |
| Alcohol SCHEMBL7078344 | 0.84 | GLA (0.43) | PTGS1ALDH1A1TSHRGLAL3MBTL1 | |
| Propylene Glycol SCHEMBL3736319 | 0.83 | HSD17B10 (0.48) | TDP1PTGS1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL48574 | 0.83 | — | — | |
| Propylene Glycol SCHEMBL28710964 | 0.82 | TDP1 (0.48) | TDP1ALDH1A1TSHRHSD17B10OR51E2 | |
| Propylene Glycol SCHEMBL151562 | 0.82 | TDP1 (0.48) | TDP1ALDH1A1TSHRHSD17B10OR51E2 | |
| Glycolic Acid SCHEMBL8982519 | 0.81 | PTGS1 (0.38) | PTGS1ALDH1A1TSHRGLAL3MBTL1 | |
| Ethylene Glycol SCHEMBL3728790 | 0.81 | ALDH1A1 (0.43) | PTGS1ALDH1A1TSHRGLAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825178-B2 | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-11-02 | — | — | US | disclosed |
| US-20070289481-A1 | Leveling Agent for Floor Polish and Aqueous Floor Polish Composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-12-20 | — | — | US | disclosed |