Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL605079 | 0.77 | HRH4 (0.66) | HRH4HRH3 | |
| SCHEMBL604018 | 0.77 | HRH4 (0.60) | HRH4HRH3HTR3A | |
| SCHEMBL2167266 | 0.72 | HRH4 (0.89) | HRH4HRH3 | |
| SCHEMBL2361195 | 0.71 | KCNH2 (0.66) | HRH4KCNH2 | |
| SCHEMBL2339285 | 0.71 | KCNH2 (0.66) | HRH4KCNH2 | |
| SCHEMBL602944 | 0.71 | HRH4 (0.60) | HRH4HRH3 | |
| SCHEMBL15857987 | 0.70 | TDO2 (0.56) | HRH4HRH3HTR3A | |
| SCHEMBL604276 | 0.70 | HRH4 (0.72) | HRH4HRH3HTR3A | |
| SCHEMBL603408 | 0.68 | HRH4 (0.56) | HRH4HRH3 | |
| SCHEMBL27738427 | 0.68 | HRH4 (0.69) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152702-A1 | AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | AstraZeneca AB (SE) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008135786-A1 | AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |