Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 3/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5029733 | 0.83 | MGMT (0.41) | MGMTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3774509 | 0.79 | JAK2 (0.52) | JAK2JAK3 | |
| SCHEMBL15390204 | 0.77 | MAPT (0.39) | MAPTKMT2AMEN1POLBGSK3A | |
| SCHEMBL3668049 | 0.76 | JAK2 (0.40) | JAK2JAK3 | |
| SCHEMBL3779697 | 0.68 | NTRK1 (0.44) | MGMTJAK2JAK3 | |
| SCHEMBL29581128 | 0.66 | MAPT (0.42) | MGMTCYP3A4MAPTSMN1; SMN2KMT2A | |
| SCHEMBL11665903 | 0.66 | MAPT (0.42) | MGMTCYP3A4MAPTSMN1; SMN2KMT2A | |
| SCHEMBL3732734 | 0.66 | APLNR (0.36) | APLNRJAK2JAK3 | |
| SCHEMBL15972473 | 0.64 | MAPT (0.41) | CYP3A4MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2578922 | 0.63 | ATM (0.39) | MGMTCYP3A4MAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155742-A1 | 5-AMINOPYRAZOL-3-YL-3H-IMIDAZO [4,5-B]PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | AstraZeneca AB (SE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008129255-A1 | 5-AMINOPYRAZOL-3-YL-3H-IMIDAZO [4,5-B] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |