Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 12/20 | 0.62 |
| ▸ | PDE4A | P27815 | 12/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.62 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743868 | 0.94 | PDE4A (0.55) | PDE4DPDE4APDE4BPDE4CPTGES | |
| SCHEMBL3735490 | 0.84 | MRGPRX4 (0.47) | PDE4DPDE4APDE4BPDE4CDAO | |
| SCHEMBL3738096 | 0.84 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CACHE | |
| SCHEMBL3739676 | 0.84 | ACHE (0.56) | PDE4DPDE4APDE4BPDE4CACHE | |
| SCHEMBL3743898 | 0.82 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CACHE | |
| SCHEMBL3744520 | 0.80 | ACHE (0.46) | DAOACHE | |
| SCHEMBL3736215 | 0.80 | ACHE (0.46) | ACHE | |
| SCHEMBL3740105 | 0.80 | DAO (0.39) | PDE4DPDE4APDE4BPDE4CDAO | |
| SCHEMBL3735670 | 0.80 | ACHE (0.46) | PDE4DPDE4APDE4BPDE4CDAO | |
| SCHEMBL3740354 | 0.79 | ACHE (0.45) | PDE4DDAOACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-B1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-12-12 | — | — | EP | disclosed |
| US-7829563-B2 | Aminoamides as orexin antagonists | HOFFMANN-LA ROCHE INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HCRTR1, HCRTR2, HRH3 | PDE4D 2656/4885PDE4A 2570/4885PDE4B 2627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.