⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL621666 | 1.00 | — | — | |
| SCHEMBL8877792 | 1.00 | — | — | |
| SCHEMBL1407387 | 0.78 | — | — | |
| SCHEMBL8052611 | 0.78 | — | — | |
| SCHEMBL1407388 | 0.78 | — | — | |
| SCHEMBL6109145 | 0.74 | CASP1 (0.30) | — | |
| SCHEMBL3904068 | 0.69 | — | — | |
| SCHEMBL503842 | 0.69 | — | — | |
| SCHEMBL692346 | 0.69 | — | — | |
| SCHEMBL1285093 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068038-A1 | (+)-(4R,6S)-(E)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1983-01-05 | — | — | EP | claimed |
| US-8735609-B2 | Bryostatin analogues, synthetic methods and uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-05-27 | — | — | US | disclosed |
| US-8497385-B2 | Bryostatin analogues, synthetic methods and uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-07-30 | — | — | US | disclosed |
| US-20130123518-A1 | Bryostatin Analogues, Synthetic Methods and Uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-05-16 | — | — | US | disclosed |
| US-20100280262-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2010-11-04 | — | — | US | disclosed |
| US-20090270492-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2009-10-29 | — | — | US | disclosed |
| US-20070270485-A1 | Byrostatin analogues, synthetic methods and uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2007-11-22 | — | — | US | disclosed |
| US-7256286-B2 | Bryostatin analogues, synthetic methods and uses | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2007-08-14 | — | — | US | disclosed |
| US-20030220334-A1 | Byrostatin analogues, synthetic methods and uses | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-11-27 | — | — | US | disclosed |
| WO-2003070719-A1 | BRYOSTATIN ANALOGUES, SYNTHETIC METHODS AND USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2003-08-28 | — | — | WO | disclosed |
| EP-0024348-B1 | SUBSTITUTED 6-PHENETHYL-AND PHENYLETHENYL-3,4,5,6-TETRAHYDRO-4-HYDROXYTETRAYDROPYRAN-2-ONES IN THE4-R TRANS STEREOISOMERIC FORMS AND THE CORRESPONDING DIHYDROXY ACIDS, PROCESS FOR PREPARING AND PHARMACEUTICAL COMPOSITION COMPRISING THEM | MERCK & CO. INC. (US) | 1985-11-13 | — | — | EP | disclosed |
| EP-0068038-B1 | (+)-(4R,6S)-(E)-6-(2-(4'-FLUORO-3,3',5-TRIMETHYL-(1,1'-BIPHENYL)-2-YL)ETHENYL)-3,4,5,6-TETRAHYDRO-4-HYDROXY-2H-PYRAN-2-ONE, A PROCESS FOR PREPARING AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | MERCK & CO. INC. (US) | 1985-09-25 | — | — | EP | disclosed |
| EP-0038061-B1 | SUBSTITUTED BIPHENYL-2-CARBOXALDEHYDES AND A PROCESS FOR PREPARING THEM | MERCK & CO. INC. (US) | 1985-01-23 | — | — | EP | disclosed |
| US-4459422-A | Substituted pyranone inhibitors of cholesterol synthesis | MERCK & CO., INC. (US) | 1984-07-10 | — | — | US | disclosed |
| EP-0010299-B1 | PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT OF HYPERCHOLESTEREMIA | MERCK & CO. INC. (US) | 1984-02-15 | — | — | EP | disclosed |
| US-4375475-A | ANTICHOLESTEROL AGENTS | MERCK & CO., INC. (US) | 1983-03-01 | — | — | US | disclosed |
| US-4322563-A | Substituted biphenyl-2-carboxaldehydes | MERCK & CO., INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4308378-A | Cis/trans isomerization of 6-(substituted-aryl-ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones | MERCK & CO., INC. (US) | 1981-12-29 | — | — | US | disclosed |
| EP-0038061-A1 | Substituted biphenyl-2-carboxaldehydes and a process for preparing them | MERCK & CO. INC. (US) | 1981-10-21 | — | — | EP | disclosed |
| EP-0010299-A1 | Pharmaceutical composition useful for the treatment of hypercholesteremia | MERCK & CO. INC. (US) | 1980-04-30 | — | — | EP | disclosed |