Sugi Predict

Sugi Predict / Compounds / SCHEMBL3734286

SCHEMBL3734286

SCHEMBL3734286

CC(=O)c1ccc(N)c(C#N)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRKCI P41743 1/20 0.47
▸ CREBBP Q92793 1/20 0.44
▸ MEN1 O00255 2/20 0.42
▸ KMT2A Q03164 2/20 0.42
▸ APAF1 O14727 1/20 0.42
▸ CYP1A2 P05177 1/20 0.41
▸ CYP3A4 P08684 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ MAPK1 P28482 1/20 0.41
▸ ADRB2 P07550 1/20 0.41
▸ ADRB1 P08588 1/20 0.41
▸ ADRB3 P13945 1/20 0.41
▸ MAPT P10636 4/20 0.40
▸ ALDH1A1 P00352 3/20 0.40
▸ TDP1 Q9NUW8 1/20 0.40
▸ CYP11B1 P15538 1/20 0.39
▸ CYP11B2 P19099 1/20 0.39
▸ NPC1 O15118 2/20 0.39
▸ RAB9A P51151 2/20 0.39
▸ PGR P06401 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30468764 1.00 PRKCI (0.47) PRKCICREBBPMEN1KMT2AAPAF1
SCHEMBL5070972 0.85 MAPK1 (0.43) CYP1A2CYP3A4TSHRMAPK1ADRB2
SCHEMBL4026182 0.83 CDC25B (0.50) TSHRMAPTALDH1A1TDP1HPGD
SCHEMBL6816025 0.83 PARP15 (0.43) CYP1A2CYP3A4TSHRMAPK1ADRB2
SCHEMBL23302174 0.81 TSHR (0.38) KMT2ACYP1A2CYP3A4TSHRMAPK1
SCHEMBL13974083 0.81 PGR (0.42) MEN1KMT2ACYP1A2CYP3A4TSHR
SCHEMBL4021525 0.81 HPGD (0.41) CYP1A2CYP3A4TSHRMAPK1ADRB2
SCHEMBL4022693 0.81 PLAU (0.45) CYP1A2CYP3A4TSHRMAPK1ADRB2
SCHEMBL13963739 0.81 PGR (0.42) KMT2ACYP1A2CYP3A4TSHRMAPK1
SCHEMBL3446199 0.81 KDM4E (0.56) MEN1KMT2AMAPK1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0158932-B1 PROCESS FOR THE PREPARATION OF 3-CYANO-4-AMINO-ACETOPHENONES Dr. Karl Thomae GmbH (DE) 1987-04-01 — — EP claimed
US-4581177-A Process for the preparation of 3-cyano-4-aminoacetophenones DR. KARL THOMAE GMBH (DE) 1986-04-08 — — US claimed
EP-0049728-A2 Method for enhancing the growth rate of meat-producing animals and for improving the lean meat to fat ratio thereof AMERICAN CYANAMID COMPANY (US) 1982-04-21 — — EP claimed
CN-119424423-A 4-Aminobut-2-enamide derivatives and salts thereof 大鹏药品工业株式会社 2025-02-14 — — CN disclosed
CN-113845548-B Platinum complex of quinazoline hydrazine dithioformate and preparation method and application thereof 深圳大学 2023-06-06 — — CN disclosed
US-20230023023-A1 4-AMINOBUT-2-ENAMIDE DERIVATIVES AND SALTS THEREOF ASTEX THERAPEUTICS LIMITED (GB) 2023-01-26 — — US disclosed
CN-115551500-A 4-aminobut-2-enamide derivatives and salts thereof 大鹏药品工业株式会社 2022-12-30 — — CN disclosed
EP-4051266-A1 4-AMINOBUT-2-ENAMIDE DERIVATIVES AND SALTS THEREOF Taiho Pharmaceutical Co., Ltd. (JP) 2022-09-07 — — EP disclosed
CN-109912434-B Synthesis method of phenylethanolamine beta receptor agonist 上海安谱实验科技股份有限公司 2022-07-12 — — CN disclosed
WO-2021085653-A1 4-AMINOBUT-2-ENAMIDE DERIVATIVES AND SALTS THEREOF TAIHO PHARMACEUTICAL CO., LTD. (JP) 2021-05-06 — — WO disclosed
WO-2021084765-A1 4-AMINOBUT-2-ENAMIDE DERIVATIVES AND SALTS THEREOF TAIHO PHARMACEUTICAL CO., LTD (JP) 2021-05-06 — — WO disclosed
US-4581177-A Process for the preparation of 3-cyano-4-aminoacetophenones DR. KARL THOMAE GMBH (DE) 1986-04-08 — — US disclosed
EP-0158932-A1 Process for the preparation of 3-cyano-4-amino-acetophenones Dr. Karl Thomae GmbH (DE) 1985-10-23 — — EP disclosed
EP-0158932-A1 Process for the preparation of 3-cyano-4-amino-acetophenones Dr. Karl Thomae GmbH (DE) 1985-10-23 — — EP disclosed
EP-0158932-A1 Process for the preparation of 3-cyano-4-amino-acetophenones Dr. Karl Thomae GmbH (DE) 1985-10-23 — — EP disclosed
US-4522822-A Phenylethane derivatives and acid addition salts thereof for increasing lean meat deposition and/or improving lean meat to fat ratio in warm blooded animals AMERICAN CYANAMID COMPANY (US) 1985-06-11 — — US disclosed
US-4501751-A Phenylethanolamine derivatives and acid addition salts thereof for enhancing the growth rate of meat-producing animals and improving the efficiency of feed utilization thereby AMERICAN CYANAMID COMPANY (US) 1985-02-26 — — US disclosed
US-4407819-A ANIMAL GROWTH REGULATORS AMERICAN CYANAMID COMPANY (US) 1983-10-04 — — US disclosed
US-4404222-A Phenylethanolamine derivatives and acid addition salts thereof for enhancing the growth rate of meat-producing animals and improving the efficiency of feed utilization thereby AMERICAN CYANAMID COMPANY (US) 1983-09-13 — — US disclosed
EP-0049728-A2 Method for enhancing the growth rate of meat-producing animals and for improving the lean meat to fat ratio thereof AMERICAN CYANAMID COMPANY (US) 1982-04-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230023023-A1 4-AMINOBUT-2-ENAMIDE DERIVATIVES AND SALTS THEREOF KRAS, NRAS, HRAS PRKCI 280/4885CREBBP 385/4885MEN1 2108/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.