Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 19/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 19/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 19/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 19/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 19/20 | 0.71 |
| ▸ | HDAC5 | Q9UQL6 | 19/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 18/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 18/20 | 0.71 |
| ▸ | HDAC10 | Q969S8 | 18/20 | 0.71 |
| ▸ | HDAC7 | Q8WUI4 | 18/20 | 0.71 |
| ▸ | HDAC9 | Q9UKV0 | 18/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | BRD4 | O60885 | 1/20 | 0.64 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | LTA4H | P09960 | 1/20 | 0.64 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.64 |
| ▸ | PLK1 | P53350 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31203399 | 0.88 | HDAC4 (0.68) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL31203459 | 0.88 | HDAC4 (0.68) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL5279007 | 0.87 | HDAC6 (0.75) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL9222067 | 0.87 | SMN1; SMN2 (0.59) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL3731214 | 0.86 | HDAC1 (0.74) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL31203302 | 0.86 | HDAC4 (0.67) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL38652239 | 0.85 | HDAC1 (0.62) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL6669511 | 0.85 | HDAC4 (0.85) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL137348 | 0.85 | HDAC4 (0.85) | HDAC4HDAC1HDAC11HDAC8HDAC6 | |
| SCHEMBL1065393 | 0.85 | HDAC4 (0.85) | HDAC4HDAC1HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100278730-A1 | Non-Invasive Molecular Imaging of Cellular Histone Deacetylase Substrate Using Magnetic Resonance Spectroscopy (MRS) or Positron Emission Tomography (PET) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2010-11-04 | — | — | US | claimed |
| WO-2009009179-A2 | NON-INVASIVE MOLECULAR IMAGING OF CELLULAR HISTONE DEACETYLASE SUBSTRATE USING MAGNETIC RESONANCE SPECTROSCOPY (MRS) OR POSITRON EMISSION TOMOGRAPHY (PET) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-01-15 | — | — | WO | claimed |
| US-20100278730-A1 | Non-Invasive Molecular Imaging of Cellular Histone Deacetylase Substrate Using Magnetic Resonance Spectroscopy (MRS) or Positron Emission Tomography (PET) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2010-11-04 | — | — | US | disclosed |
| WO-2009009179-A2 | NON-INVASIVE MOLECULAR IMAGING OF CELLULAR HISTONE DEACETYLASE SUBSTRATE USING MAGNETIC RESONANCE SPECTROSCOPY (MRS) OR POSITRON EMISSION TOMOGRAPHY (PET) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100278730-A1 | Non-Invasive Molecular Imaging of Cellular Histone Deacetylase Substrate Using Magnetic Resonance Spectroscopy (MRS) or Positron Emission Tomography (PET) | HDAC1, HDAC3, HDAC10 | HDAC4 8/4885HDAC1 1/4885HDAC11 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.