Pirlindole

Pirlindole

SCHEMBL373564

Cc1ccc2c(c1)c1c3n2CCNC3CCC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 7/20 1.00
MEN1 O00255 6/20 1.00
KMT2A Q03164 6/20 1.00
KDM4E B2RXH2 6/20 1.00
CYP1A2 P05177 3/20 1.00
CYP2D6 P10635 3/20 1.00
TP53 P04637 3/20 1.00
CYP3A4 P08684 2/20 1.00
TEAD4 Q15561 2/20 1.00
HTR1A P08908 1/20 1.00
ADRA2A P08913 1/20 1.00
CHRM1 P11229 1/20 1.00
MAOA P21397 1/20 1.00
DRD1 P21728 1/20 1.00
SLC6A2 P23975 1/20 1.00
TEAD1 P28347 1/20 1.00
SLC6A4 P31645 1/20 1.00
SLC6A3 Q01959 1/20 1.00
KCNH2 Q12809 1/20 1.00
TEAD2 Q15562 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pirlindole SCHEMBL29500947 1.00 HSD17B10 (1.00) HSD17B10MEN1KMT2AKDM4ECYP1A2
Pirlindole SCHEMBL18877133 1.00 HSD17B10 (1.00) HSD17B10MEN1KMT2AKDM4ECYP1A2
Pirlindole SCHEMBL18878061 1.00 HSD17B10 (1.00) HSD17B10MEN1KMT2AKDM4ECYP1A2
Pirlindole SCHEMBL4157397 0.99 HSD17B10 (0.97) HSD17B10MEN1KMT2AKDM4ECYP1A2
Pirlindole SCHEMBL1649683 0.97 HSD17B10 (0.95) HSD17B10MEN1KMT2AKDM4ECYP1A2
SCHEMBL4152460 0.94 HSD17B10 (1.00) HSD17B10MEN1KMT2AKDM4ECYP1A2
Pirlindole SCHEMBL30984462 0.92 HSD17B10 (1.00) HSD17B10MEN1KMT2AKDM4ECYP1A2
Pirlindole SCHEMBL3761340 0.92 HSD17B10 (1.00) HSD17B10MEN1KMT2AKDM4ECYP1A2
Pirlindole SCHEMBL17241165 0.83 HSD17B10 (0.68) HSD17B10MEN1KMT2AKDM4ECYP1A2
SCHEMBL13702963 0.82 KMT2A (0.98) HSD17B10MEN1KMT2AKDM4ECYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2208 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250339403-A1 Tryptamine Formulations and Uses Thereof Natural MedTech Pty Ltd (AU) 2025-11-06 US claimed
EP-4633638-A1 TREATMENT OF PSYCHOLOGICAL FACTORS AFFECTING OTHER MEDICAL CONDITIONS (PFAOMC) Luminous Mind Inc. (US) 2025-10-22 EP claimed
EP-4618981-A1 COMBINATIONS OF MONOAMINE OXIDASE INHIBITORS AND SEROTONIN RECEPTOR AGONISTS AND THEIR THERAPEUTIC USE Remedi, Inc. (US) 2025-09-24 EP claimed
EP-4615444-A1 TRYPTAMINE FORMULATIONS AND USES THEREOF Natural Medtech Pty Ltd (AU) 2025-09-17 EP claimed
US-12396982-B2 Compositions of matter and pharmaceutical compositions ATAI THERAPEUTICS, INC. (US) 2025-08-26 US claimed
WO-2025151884-A1 USE OF GLYCOSAMINOGLYCAN SULFATED POLYSACCHARIDES SUCH AS SODIUM PENTOSAN POLYSULFATE IN COMBINATION WITH PERMEATION AGENTS TO TREAT ALZHEIMER'S DISEASE PARSONS C LOWELL (US) 2025-07-17 WO claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-20250041273-A1 NOVEL COMPOSITIONS OF MATTER AND PHARMACEUTICAL COMPOSITIONS ATAI LIFE SCIENCES N.V. (DE) 2025-02-06 US claimed
EP-4479032-A1 NEUROACTIVE STEROIDS FOR TREATMENT OF CNS-RELATED DISORDERS Sage Therapeutics, Inc. (US) 2024-12-25 EP claimed
US-20240408059-A1 METHOD OF TREATING ADDICTION ANEBULO PHARMACEUTICALS, INC. 2024-12-12 US claimed
EP-1210080-A2 USE OF MONOAMINE OXIDASE INHIBITORS FOR THE MANUFACTURE OF DRUGS INTENDED FOR THE TREATMENT OF OBESITY Sanofi-Aventis (FR) 2002-06-05 EP claimed
WO-2002041883-A2 AS-NEEDED ADMINISTRATION OF TRICYCLIC AND OTHER NON-SRI ANTIDEPRESSANT DRUGS TO TREAT PREMATURE EJACULATION VIVUS, INC. (US) 2002-05-30 WO claimed
US-20020037828-A1 Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation VIVUS, INC. 2002-03-28 US claimed
EP-1150715-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING NICOTINE OR A LIGAND OF NICOTINE RECEPTORS AND A MONAMINE OXYDASE INHIBITOR AND THEIR USE FOR TREATING TOBACCO WITHDRAWAL SYMPTOMS SANOFI-SYNTHELABO (FR) 2001-11-07 EP claimed
US-20010008896-A1 Administration of active agents, including 5-HT receptor agonists and antagonists, to treat premature ejaculation SMITH WILLIAM L (US) 2001-07-19 US claimed
EP-1078632-A1 Use of monoamine oxydase inhibitors for the manufacture of drugs intended for the treatment of obesity SANOFI-SYNTHELABO (FR) 2001-02-28 EP claimed
WO-2001012176-A2 USE OF MONOAMINE OXIDASE INHIBITORS FOR THE MANUFACTURE OF DRUGS INTENDED FOR THE TREATMENT OF OBESITY SANOFI-SYNTHELABO (FR) 2001-02-22 WO claimed
WO-2000045846-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING NICOTINE OR A LIGAND OF NICOTINE RECEPTORS AND A MONAMINE OXYDASE INHIBITOR AND THEIR USE FOR TREATING TOBACCO WITHDRAWAL SYMPTOMS SANOFI-SYNTHELABO (FR) 2000-08-10 WO claimed
US-5922341-A Local administration of pharmacologically active agents to treat premature ejaculation VIVUS, INCORPORATED (US) 1999-07-13 US claimed
WO-1999013879-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING A MONOAMINE OXYDASE INHIBITOR AND THEIR USE IN THERAPY SANOFI-SYNTHELABO (FR) 1999-03-25 WO claimed