Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.98 |
| ▸ | MEN1 | O00255 | 7/20 | 0.98 |
| ▸ | MAPT | P10636 | 7/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.98 |
| ▸ | TP53 | P04637 | 4/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 4/20 | 0.85 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.85 |
| ▸ | CCR6 | P51684 | 2/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.70 |
| ▸ | GAA | P10253 | 4/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2509281 | 0.99 | KMT2A (1.00) | KMT2AMEN1MAPTALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL9849090 | 0.98 | KMT2A (0.98) | KMT2AMEN1MAPTALDH1A1TP53 | |
| Pirlindole SCHEMBL29500947 | 0.82 | HSD17B10 (1.00) | KMT2AMEN1MAPTALDH1A1TP53 | |
| Pirlindole SCHEMBL18878061 | 0.82 | HSD17B10 (1.00) | KMT2AMEN1MAPTALDH1A1TP53 | |
| Pirlindole SCHEMBL373564 | 0.82 | HSD17B10 (1.00) | KMT2AMEN1MAPTALDH1A1TP53 | |
| Pirlindole SCHEMBL18877133 | 0.82 | HSD17B10 (1.00) | KMT2AMEN1MAPTALDH1A1TP53 | |
| SCHEMBL12922443 | 0.82 | KMT2A (0.68) | KMT2AMEN1MAPTALDH1A1TP53 | |
| Pirlindole SCHEMBL4157397 | 0.81 | HSD17B10 (0.97) | KMT2AMEN1MAPTALDH1A1TP53 | |
| Pirlindole SCHEMBL1649683 | 0.81 | HSD17B10 (0.95) | KMT2AMEN1MAPTALDH1A1TP53 | |
| SCHEMBL3174932 | 0.79 | HSD17B10 (0.97) | KMT2AMEN1MAPTALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9980942-B2 | Rejuvenation of precursor cells | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2018-05-29 | — | — | US | disclosed |
| US-9433663-B2 | Mobilization of hematopoietic stem cells | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2016-09-06 | — | — | US | disclosed |
| US-20150297563-A1 | REJUVENATION OF PRECURSOR CELLS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-22 | — | — | US | disclosed |
| WO-2013166043-A1 | REJUVENATION OF PRECURSOR CELLS | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2013-11-07 | — | — | WO | disclosed |
| US-20130202553-A1 | MOBILIZATION OF HEMATOPOIETIC STEM CELLS | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2013-08-08 | — | — | US | disclosed |
| WO-2009114725-A2 | MOBILIZATION OF HEMATOPOIETIC STEM CELLS | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130202553-A1 | MOBILIZATION OF HEMATOPOIETIC STEM CELLS | CDC42, CDC45, CDC42BPG | KMT2A 2939/4885MEN1 1827/4885MAPT 4599/4885 |
| US-20150297563-A1 | REJUVENATION OF PRECURSOR CELLS | CDC42, RAPGEF3, HRAS | KMT2A 3614/4885MEN1 3618/4885MAPT 3235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.