Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699835 | 0.87 | AKR1C1 (0.45) | OPRM1AKR1C1OPRD1OPRK1OPRL1 | |
| SCHEMBL11602249 | 0.86 | OPRM1 (0.50) | OPRM1HTR2ATACR1HDAC1OPRD1 | |
| SCHEMBL23647372 | 0.86 | OPRM1 (0.47) | OPRM1HTR2ATACR1HDAC1AKR1C1 | |
| SCHEMBL24943664 | 0.85 | OPRM1 (0.46) | OPRM1HTR2ATACR1HDAC1 | |
| SCHEMBL24944239 | 0.85 | OPRM1 (0.49) | OPRM1HTR2ATACR1HDAC1AKR1C1 | |
| SCHEMBL26413968 | 0.84 | OPRM1 (0.46) | OPRM1TACR1OPRD1OPRK1 | |
| SCHEMBL26413963 | 0.84 | OPRM1 (0.46) | OPRM1TACR1OPRD1OPRK1 | |
| SCHEMBL24944034 | 0.83 | OPRM1 (0.48) | OPRM1HTR2ATACR1HDAC1OPRD1 | |
| SCHEMBL373820 | 0.83 | OPRM1 (0.48) | OPRM1HTR2ATACR1HDAC1CYP1A2 | |
| SCHEMBL24944640 | 0.83 | OPRM1 (0.48) | OPRM1HTR2ATACR1HDAC1AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583587-A2 | ORGANIC COMPOUNDS WITH BIOLOGICAL ACTION AS THROMBIN INHIBITORS AND USE THEROF | CPI Creative Pharma International GmbH (DE) | 2005-10-12 | — | — | EP | claimed |
| WO-2004063212-A2 | ORGANIC COMPOUNDS WITH BIOLOGICAL ACTION AS THROMBIN INHIBITORS AND USE THEROF | CPI CREATIVE PHARMA INTERNATIONAL GMBH (DE) | 2004-07-29 | — | — | WO | claimed |
| EP-1425296-A1 | ORGANIC COMPOUNDS WITH BIOLOGICAL ACTIVITY AS THROMBIN INHIBITORS AND USE THEREOF | Novel Science International Gmbh (DE) | 2004-06-09 | — | — | EP | claimed |
| WO-2003022873-A9 | ORGANIC COMPOUNDS WITH BIOLOGICAL ACTIVITY AS THROMBIN INHIBITORS AND USE THEREOF | NOVEL SCIENCE INTERNAT GMBH (DE) | 2003-12-11 | — | — | WO | claimed |
| WO-2003022873-A1 | ORGANIC COMPOUNDS WITH BIOLOGICAL ACTIVITY AS THROMBIN INHIBITORS AND USE THEREOF | NOVEL SCIENCE INTERNATIONAL GMBH (DE) | 2003-03-20 | — | — | WO | claimed |
| EP-2610258-B1 | Substituted piperidino dihydrothieno pyrimidines | BOEHRINGER INGELHEIM INT (DE) | 2014-08-27 | — | — | EP | disclosed |
| EP-2380891-B1 | Substituted piperidino-dihydrothienopyrimidines | BOEHRINGER INGELHEIM INT (DE) | 2013-12-11 | — | — | EP | disclosed |
| EP-2610258-A1 | Substituted piperidino dihydrothieno pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-03 | — | — | EP | disclosed |
| EP-2215092-B1 | SUBSTITUTED PIPERIDINO-DIHYDROTHIENOPYRIMIDINES | BOEHRINGER INGELHEIM INT (DE) | 2012-01-25 | — | — | EP | disclosed |
| EP-2181731-B1 | Organic compounds with biological effect as thrombin inhibitor and use of same | CPI CREATIVE PHARMA INTERNAT GMBH (DE) | 2011-12-28 | — | — | EP | disclosed |
| EP-2380891-A1 | Substituted piperidino-dihydrothienopyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-1425296-B1 | ORGANIC COMPOUNDS WITH BIOLOGICAL ACTIVITY AS THROMBIN INHIBITORS AND USE THEREOF | NOVEL SCIENCE INTERNAT GMBH (DE) | 2011-04-13 | — | — | EP | disclosed |
| EP-2215092-A1 | SUBSTITUTED PIPERIDINO-DIHYDROTHIENOPYRIMIDINES | Boehringer Ingelheim International GmbH (DE) | 2010-08-11 | — | — | EP | disclosed |
| EP-2181731-A1 | Organic compounds with biological effect as thrombin inhibitor and use of same | CPI Creative Pharma International GmbH (DE) | 2010-05-05 | — | — | EP | disclosed |
| WO-2009050248-A1 | SUBSTITUTED PIPERIDINO-DIHYDROTHIENOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |
| EP-1583587-A2 | ORGANIC COMPOUNDS WITH BIOLOGICAL ACTION AS THROMBIN INHIBITORS AND USE THEROF | CPI Creative Pharma International GmbH (DE) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004063212-A2 | ORGANIC COMPOUNDS WITH BIOLOGICAL ACTION AS THROMBIN INHIBITORS AND USE THEROF | CPI CREATIVE PHARMA INTERNATIONAL GMBH (DE) | 2004-07-29 | — | — | WO | disclosed |
| EP-1425296-A1 | ORGANIC COMPOUNDS WITH BIOLOGICAL ACTIVITY AS THROMBIN INHIBITORS AND USE THEREOF | Novel Science International Gmbh (DE) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003022873-A9 | ORGANIC COMPOUNDS WITH BIOLOGICAL ACTIVITY AS THROMBIN INHIBITORS AND USE THEREOF | NOVEL SCIENCE INTERNAT GMBH (DE) | 2003-12-11 | — | — | WO | disclosed |
| WO-2003022873-A1 | ORGANIC COMPOUNDS WITH BIOLOGICAL ACTIVITY AS THROMBIN INHIBITORS AND USE THEREOF | NOVEL SCIENCE INTERNATIONAL GMBH (DE) | 2003-03-20 | — | — | WO | disclosed |