Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 1.00 |
| ▸ | NPC1 | O15118 | 12/20 | 0.93 |
| ▸ | RAB9A | P51151 | 12/20 | 0.93 |
| ▸ | MAPT | P10636 | 5/20 | 0.93 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.93 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.93 |
| ▸ | RELA | Q04206 | 2/20 | 0.93 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.93 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.75 |
| ▸ | TSHR | P16473 | 2/20 | 0.75 |
| ▸ | HTT | P42858 | 2/20 | 0.75 |
| ▸ | TP53 | P04637 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5959967 | 0.92 | SMN1; SMN2 (0.85) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL1473020 | 0.90 | NR1H4 (1.00) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL13417120 | 0.88 | NPC1 (0.79) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL321073 | 0.86 | NR1H4 (0.91) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL17640602 | 0.86 | NR1H4 (0.91) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL20968200 | 0.85 | RAB9A (0.74) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL5959951 | 0.84 | SMN1; SMN2 (0.84) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL12895776 | 0.82 | NR1H4 (0.83) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL13416880 | 0.82 | NPC1 (0.73) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL2463534 | 0.81 | SMN1; SMN2 (0.93) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160354375-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES | ELECTROPHORETICS LIMITED (GB) | 2016-12-08 | — | — | US | disclosed |
| US-7834039-B2 | Oxadiazole compounds | ABBOTT LABORATORIES (US) | 2010-11-16 | — | — | US | disclosed |
| US-7834039-B2 | Oxadiazole compounds | ABBOTT LABORATORIES (US) | 2010-11-16 | — | — | US | disclosed |
| US-7834039-B2 | Oxadiazole compounds | ABBOTT LABORATORIES (US) | 2010-11-16 | — | — | US | disclosed |
| EP-2109364-A1 | NOVEL OXADIAZOLE COMPOUNDS | Abbott Laboratories (US) | 2009-10-21 | — | — | EP | disclosed |
| US-20080280876-A1 | Novel oxadiazole compounds | ABBVIE INC. | 2008-11-13 | — | — | US | disclosed |
| US-20080280876-A1 | Novel oxadiazole compounds | ABBVIE INC. | 2008-11-13 | — | — | US | disclosed |
| US-20080280876-A1 | Novel oxadiazole compounds | ABBVIE INC. | 2008-11-13 | — | — | US | disclosed |
| WO-2008076356-A1 | NOVEL OXADIAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2008-06-26 | — | — | WO | disclosed |
| US-5712285-A | Pyrrolo-pyridine derivatives | MERCK, SHARP & DOHME, LTD. (GB) | 1998-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160354375-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES | CSNK1G1, CSNK1A1, CSNK1D | SMN1; SMN2 571/4885NPC1 1170/4885RAB9A 2711/4885 |
| US-20080280876-A1 | Novel oxadiazole compounds | S1PR3, S1PR1, S1PR2 | SMN1; SMN2 3564/4885NPC1 1268/4885RAB9A 2582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.