SCHEMBL373735

SCHEMBL373735

COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)OC(=O)C(C)N)n(-c5ccccc5)c4=O)cc3F)ccnc2c1

nearest known ligand 0.84

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MET P08581 20/20 0.84
KDR P35968 20/20 0.84
IGF1R P08069 18/20 0.84
MST1R Q04912 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL373669 1.00 MET (0.84) METKDRIGF1RMST1R
SCHEMBL3674530 1.00 MET (0.84) METKDRIGF1RMST1R
SCHEMBL373934 1.00 MET (0.84) METKDRIGF1RMST1R
SCHEMBL373734 1.00 MET (0.84) METKDRIGF1RMST1R
Hydrochloric Acid SCHEMBL373920 0.99 MET (0.83) METKDRIGF1RMST1R
Hydrochloric Acid SCHEMBL17727663 0.99 MET (0.83) METKDRIGF1RMST1R
Hydrochloric Acid SCHEMBL17727667 0.99 MET (0.83) METKDRIGF1RMST1R
Hydrochloric Acid SCHEMBL3673859 0.99 MET (0.83) METKDRIGF1RMST1R
Hydrochloric Acid SCHEMBL373992 0.99 MET (0.83) METKDRIGF1RMST1R
Oxalic Acid SCHEMBL376835 0.99 MET (0.82) METKDRIGF1RMST1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2408300-A1 AMINO ESTER DERIVATIVES, SALTS THEREOF AND METHODS OF USE Sunshine Lake Pharma Co., Ltd (CN) 2012-01-25 EP disclosed
WO-2010111063-A1 AMINO ESTER DERIVATIVES, SALTS THEREOF AND METHODS OF USE XI NING (US) 2010-09-30 WO disclosed