Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 20/20 | 0.82 |
| ▸ | CCR5 | P51681 | 13/20 | 0.82 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.66 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3737417 | 1.00 | CCR2 (0.82) | CCR2CCR5CHRM2CHRM4CHRM1 | |
| SCHEMBL3737419 | 1.00 | CCR2 (0.82) | CCR2CCR5CHRM2CHRM4CHRM1 | |
| SCHEMBL3737129 | 0.93 | CCR2 (0.80) | CCR2CCR5CHRM2CHRM4CHRM1 | |
| SCHEMBL3737131 | 0.93 | CCR2 (0.80) | CCR2CCR5CHRM2CHRM4CHRM1 | |
| SCHEMBL3737130 | 0.93 | CCR2 (0.80) | CCR2CCR5CHRM2CHRM4CHRM1 | |
| SCHEMBL4415377 | 0.91 | CCR2 (0.77) | CCR2CCR5CHRM2CHRM4CHRM1 | |
| SCHEMBL4415381 | 0.91 | CCR2 (0.77) | CCR2CCR5CHRM2CHRM4CHRM1 | |
| SCHEMBL4415383 | 0.91 | CCR2 (0.77) | CCR2CCR5CHRM2CHRM4CHRM1 | |
| SCHEMBL3737065 | 0.90 | CCR2 (1.00) | CCR2CCR5CHRM2CHRM4CHRM1 | |
| SCHEMBL3737069 | 0.90 | CCR2 (1.00) | CCR2CCR5CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656345-B1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2013-10-16 | — | — | EP | claimed |
| US-7829571-B2 | Cyclic derivatives as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-11-09 | — | — | US | disclosed |