Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 19/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931046 | 0.77 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL18121917 | 0.74 | CRHR1 (0.89) | CRHR1 | |
| SCHEMBL7434787 | 0.65 | CRHR1 (0.57) | CRHR1 | |
| SCHEMBL10313479 | 0.63 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL5600192 | 0.63 | CRHR1 (0.84) | CRHR1 | |
| SCHEMBL6496687 | 0.61 | CRHR1 (0.54) | CRHR1 | |
| Hydrochloric Acid SCHEMBL5826964 | 0.61 | CRHR1 (0.53) | CRHR1 | |
| Hydrochloric Acid SCHEMBL5826614 | 0.61 | CRHR1 (0.53) | CRHR1 | |
| Hydrochloric Acid SCHEMBL5826605 | 0.61 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL5232112 | 0.61 | TACR2 (0.60) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9555032-B2 | Methods for treatment and prevention of tauopathies and amyloid beta amyloidosis by modulating CRF receptor signaling | RESEARCH DEVELOPMENT FOUNDATION (US) | 2017-01-31 | — | — | US | disclosed |
| US-20100278743-A1 | METHODS FOR TREATMENT AND PREVENTION OF TAUOPATHIES AND AMYLOID BETA AMYLOIDOSIS BY MODULATING CRF RECEPTOR SIGNALING | RESEARCH DEVELOPMENT FOUNDATION (US) | 2010-11-04 | — | — | US | disclosed |