Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743204 | 0.90 | MAPT (0.39) | MAPTTP53TDP1LMNASMN1; SMN2 | |
| SCHEMBL3727382 | 0.90 | KDM4E (0.37) | TP53ALDH1A1L3MBTL1KDM4EHPGD | |
| SCHEMBL3716849 | 0.90 | MAPT (0.43) | MAPTTP53TDP1LMNASMN1; SMN2 | |
| SCHEMBL3723302 | 0.88 | MAPT (0.42) | MAPTTP53TDP1LMNASMN1; SMN2 | |
| SCHEMBL3739575 | 0.88 | MAPT (0.42) | MAPTTP53TDP1LMNASMN1; SMN2 | |
| SCHEMBL3732959 | 0.87 | MAPT (0.41) | MAPTTP53TDP1LMNASMN1; SMN2 | |
| SCHEMBL3717081 | 0.83 | MAPT (0.46) | MAPTTP53TDP1LMNASMN1; SMN2 | |
| SCHEMBL3729807 | 0.81 | TDP1 (0.39) | MAPTTP53TDP1LMNASMN1; SMN2 | |
| SCHEMBL3729810 | 0.81 | TDP1 (0.39) | MAPTTP53TDP1LMNASMN1; SMN2 | |
| SCHEMBL3731410 | 0.80 | KDM4E (0.34) | TP53ALDH1A1L3MBTL1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372842-B2 | Pyrazolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2013-02-12 | — | — | US | disclosed |
| CN-101965347-B | Pyrazolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC | 2013-01-02 | — | — | CN | disclosed |
| EP-2242757-B1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2012-08-01 | — | — | EP | disclosed |
| CN-101965347-A | Pyrazolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC | 2011-02-02 | — | — | CN | disclosed |
| US-20100280043-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280043-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | CHEK2, CHEK1, BUB1B | MAPT 3636/4885TP53 46/4885TDP1 144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.