SCHEMBL373886

SCHEMBL373886

CC(=O)OC1(CO)CC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15492447 0.80
SCHEMBL15129906 0.79 EPHX1 (0.39)
SCHEMBL595473 0.78
SCHEMBL28931795 0.78
SCHEMBL3019126 0.76 CYP2C19 (0.35)
SCHEMBL27782458 0.76
SCHEMBL2434532 0.76
SCHEMBL31547 0.76 ALDH1A1 (0.33)
SCHEMBL27804006 0.76
SCHEMBL3831144 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4003355-A1 DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES Janssen Sciences Ireland Unlimited Company (IE) 2022-06-01 EP disclosed
WO-2021018237-A1 DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES Janssen Sciences Ireland Unlimited Company (IE) 2021-02-04 WO disclosed
EP-3164388-A1 HETEROCYCLIC COMPOUNDS AND THEIR USE AS RETINOID-RELATED ORPHAN RECEPTOR (ROR) GAMMA-T INHIBITORS Takeda Pharmaceutical Company Limited (JP) 2017-05-10 EP disclosed
US-9630924-B2 Heterocyclic compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-04-25 US disclosed
US-20160176872-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL (JP) 2016-06-23 US disclosed
EP-2408300-B1 AMINO ESTER DERIVATIVES, SALTS THEREOF AND METHODS OF USE SUNSHINE LAKE PHARMA CO LTD (CN) 2016-05-11 EP disclosed
WO-2016002968-A1 HETEROCYCLIC COMPOUNDS AND THEIR USE AS RETINOID-RELATED ORPHAN RECEPTOR (ROR) GAMMA-T INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-01-07 WO disclosed
US-20160002169-A1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-01-07 US disclosed
CN-102638981-A Substituted piperidines that increase p53 activity and uses thereof SCHERING CORP 2012-08-15 CN disclosed
US-8232294-B2 Amino ester derivatives, sailts thereof and methods of use Xi, Ning (US) 2012-07-31 US disclosed
EP-2408300-A1 AMINO ESTER DERIVATIVES, SALTS THEREOF AND METHODS OF USE Sunshine Lake Pharma Co., Ltd (CN) 2012-01-25 EP disclosed
CN-102212062-A Derivative of amino ester, salt thereof and using method DONGGUAN CHANGAN EAST SUNSHINE DRUG R & D CO LTD 2011-10-12 CN disclosed
US-7829716-B2 decyclization of {3-[(E)-2(7-chloro-2-quinolinyl)vinyl]phenyl}-4,5-dihydro-3H-benzo[c]thiepin-1-one by methylmagnesium halide with following conversion to montelukast Synthon Pharmaceuticals, Inc. (US) 2010-11-09 US disclosed
WO-2010111063-A1 AMINO ESTER DERIVATIVES, SALTS THEREOF AND METHODS OF USE XI NING (US) 2010-09-30 WO disclosed
US-20100239576-A1 AMINO ESTER DERIVATIVES, SAILTS THEREOF AND METHODS OF USE SUNSHINE LAKE PHARMA CO., LTD. (CN) 2010-09-23 US disclosed
EP-2162436-A1 NOVEL CASE OF RENIN INHIBITORS Merck Frosst Canada Ltd. (CA) 2010-03-17 EP disclosed
WO-2008141462-A9 NOVEL CASE OF RENIN INHIBITORS MERCK FROSST CANADA LTD (CA) 2009-01-08 WO disclosed
WO-2008141462-A1 NOVEL CASE OF RENIN INHIBITORS MERCK FROSST CANADA LTD. (CA) 2008-11-27 WO disclosed
US-20050245568-A1 Process for making montelukast and intermediates therefor SYNTHON BV (NL) 2005-11-03 US disclosed
US-6268395-B1 FOR EXAMPLE ANTI-HIV AGENT; HAVING HIGHER ANTIVIRAL EFFECTS AND LESS DELETERIOUS SIDE EFFECTS AS COMPARED WITH CONVENTIONALLY KNOWN ANTIVIRAL AGENTS. LEAD CHEMICAL CO., LTD. (JP) 2001-07-31 US disclosed