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Sugi Predict / Compounds / SCHEMBL3739636

SCHEMBL3739636

SCHEMBL3739636

CC(C)[C@H](N)C(=O)OCC(C)(C)NC(=O)OCOP(=O)(OCOC(=O)NC(C)(C)COC(=O)[C@@H](N)C(C)C)C(O)(CCCN)P(=O)(O)O

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ FDPS P14324 5/20 0.37
▸ PDE3A Q14432 2/20 0.37
▸ LMNA P02545 1/20 0.31
▸ ADRB3 P13945 1/20 0.31
▸ PDE4D Q08499 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7855128 0.85 FDPS (0.40) FDPSPDE3ALMNAADRB3PDE4D
SCHEMBL3726963 0.85 FDPS (0.40) FDPSPDE3ALMNAADRB3PDE4D
SCHEMBL7865325 0.81 FDPS (0.38) FDPSPDE3A
SCHEMBL5995945 0.80 FDPS (0.41) FDPSPDE3ALMNAADRB3PDE4D
SCHEMBL3735502 0.80 FDPS (0.41) FDPSPDE3ALMNAADRB3PDE4D
SCHEMBL7861999 0.79 FDPS (0.40) FDPSPDE3ALMNAADRB3PDE4D
SCHEMBL7860534 0.79 FDPS (0.40) FDPSPDE3ALMNAADRB3PDE4D
SCHEMBL3728830 0.79 FDPS (0.38) FDPSPDE3A
SCHEMBL7862907 0.77 FDPS (0.47) FDPSPDE3ALMNAADRB3PDE4D
SCHEMBL7855065 0.76 FDPS (0.40) FDPSPDE3ALMNAADRB3PDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7825238-B2 Antiviral methods employing double esters of 2′, 3′-dideoxy-3′-fluoroguanosine MEDIVIR AB (SE) 2010-11-02 — — US disclosed
US-6974802-B2 Treatment of viral infections using prodrugs of 2′,3-dideoxy,3′-fluoroguanosine MEDIVIR AB (SE) 2005-12-13 — — US disclosed
US-6458772-B1 Prodrugs MEDIVIR AB (SE) 2002-10-01 — — US disclosed