Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trovafloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.90 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.87 |
| ▸ | FLT4 | P35916 | 1/20 | 0.87 |
| ▸ | GSK3B | P49841 | 1/20 | 0.87 |
| ▸ | RARB | P10826 | 1/20 | 0.87 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.87 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | POLB | P06746 | 1/20 | 0.79 |
| ▸ | HPGD | P15428 | 1/20 | 0.79 |
| ▸ | XBP1 | P17861 | 1/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.79 |
| ▸ | HTT | P42858 | 1/20 | 0.79 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.79 |
| ▸ | RELA | Q04206 | 1/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.79 |
| ▸ | DPP4 | P27487 | 4/20 | 0.51 |
| ▸ | TOP2A | P11388 | 11/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tosufloxacin SCHEMBL34355 | 0.95 | KMT2A (1.00) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL29383684 | 0.95 | KMT2A (1.00) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL9323984 | 0.95 | KMT2A (1.00) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL34354 | 0.95 | KMT2A (1.00) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL9180975 | 0.94 | EPHA2 (0.88) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL9180983 | 0.94 | EPHA2 (0.88) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL9180985 | 0.94 | EPHA2 (0.88) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL9691106 | 0.94 | KMT2A (0.98) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL19149806 | 0.94 | KMT2A (0.98) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL3754459 | 0.94 | KMT2A (0.98) | KMT2AEPHA2FLT4GSK3BRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560634-A1 | NITRIC OXIDE RELEASING PRODRUGS OF THERAPEUTIC AGENTS | Piramal Enterprises Limited (IN) | 2013-02-27 | — | — | EP | disclosed |
| EP-2409702-A1 | Combination of siloxane and active ingredient for treating dental disorder of hard tissues | Bayer Innovation GmbH (DE) | 2012-01-25 | — | — | EP | disclosed |
| WO-2011132171-A1 | NITRIC OXIDE RELEASING PRODRUGS OF THERAPEUTIC AGENTS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-10-27 | — | — | WO | disclosed |