Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.77 |
| ▸ | FLT4 | P35916 | 1/20 | 0.77 |
| ▸ | GSK3B | P49841 | 1/20 | 0.77 |
| ▸ | RARB | P10826 | 1/20 | 0.77 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.77 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | XBP1 | P17861 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.70 |
| ▸ | RELA | Q04206 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | DPP4 | P27487 | 2/20 | 0.53 |
| ▸ | TOP2A | P11388 | 13/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tosufloxacin SCHEMBL34354 | 1.00 | KMT2A (1.00) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL34355 | 1.00 | KMT2A (1.00) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL29383684 | 1.00 | KMT2A (1.00) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL28308419 | 0.99 | KMT2A (0.98) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL19149806 | 0.99 | KMT2A (0.98) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL3754459 | 0.99 | KMT2A (0.98) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL9691106 | 0.99 | KMT2A (0.98) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL9691051 | 0.97 | KMT2A (0.93) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL2326609 | 0.96 | KMT2A (0.92) | KMT2AEPHA2FLT4GSK3BRARB | |
| Trovafloxacin SCHEMBL373984 | 0.95 | KMT2A (0.90) | KMT2AEPHA2FLT4GSK3BRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0331960-B1 | Process for the preparation of enantiomerically homogeneous aminopyrrolidinyl naphthyridine and quinolone carboxylic acids | ABBOTT LAB (US) | 1994-05-18 | — | — | EP | claimed |
| EP-0331960-A2 | Process for the preparation of enantiomerically homogeneous aminopyrrolidinyl naphthyridine and quinolone carboxylic acids | ABBOTT LABORATORIES (US) | 1989-09-13 | — | — | EP | claimed |
| US-4859776-A | (S)-7-(3-aminopyrrolidin-1-yl)-1-(ortho, para-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid and method for its preparation | ABBOTT LABORATORIES (US) | 1989-08-22 | — | — | US | claimed |
| US-5359088-A | Chemical intermediates | ABBOTT LABORATORIES (US) | 1994-10-25 | — | — | US | disclosed |
| EP-0331960-B1 | Process for the preparation of enantiomerically homogeneous aminopyrrolidinyl naphthyridine and quinolone carboxylic acids | ABBOTT LAB (US) | 1994-05-18 | — | — | EP | disclosed |
| US-5099032-A | Aminopyrroles formed from hydroxypyrroles by displacement | ABBOTT LABORATORIES (US) | 1992-03-24 | — | — | US | disclosed |
| US-4956475-A | REDUCTIVE ACETYLATION OF THE 3-AZIDO DERIVATIVE USING THIOACETIC ACID TO OBTAIN THE CORRESPONDING ACETAMIDE | ABBOTT LABORATORIES (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0331960-A2 | Process for the preparation of enantiomerically homogeneous aminopyrrolidinyl naphthyridine and quinolone carboxylic acids | ABBOTT LABORATORIES (US) | 1989-09-13 | — | — | EP | disclosed |
| US-4859776-A | (S)-7-(3-aminopyrrolidin-1-yl)-1-(ortho, para-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid and method for its preparation | ABBOTT LABORATORIES (US) | 1989-08-22 | — | — | US | disclosed |