Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3752444 | 0.77 | SLC6A4 (0.31) | SLC6A4 | |
| SCHEMBL3702103 | 0.76 | CHRNB2 (0.32) | HTR2AHTR2CHTR2BKCNH2CHRNB2 | |
| SCHEMBL10200444 | 0.74 | HTR2A (0.40) | HTR2AHTR2CHTR2BKCNH2CHRNB2 | |
| Hydrochloric Acid SCHEMBL2106541 | 0.73 | HTR2A (0.39) | HTR2AHTR2CHTR2BKCNH2CHRNB2 | |
| SCHEMBL3747615 | 0.70 | CHRNB2 (0.34) | HTR2AHTR2CHTR2BKCNH2CHRNB2 | |
| SCHEMBL3706859 | 0.68 | MEN1 (0.38) | HTR2AHTR2CHTR2BKCNH2CHRNB2 | |
| SCHEMBL3706863 | 0.68 | MEN1 (0.38) | HTR2AHTR2CHTR2BKCNH2CHRNB2 | |
| SCHEMBL3702568 | 0.68 | CHRNB2 (0.31) | HTR2AHTR2CHTR2BCHRNB2CHRNB4 | |
| SCHEMBL13970709 | 0.66 | — | — | |
| SCHEMBL3745574 | 0.66 | HTR2A (0.31) | HTR2AHTR2CHTR2BKCNH2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132015-A1 | NEW COMPOUNDS MODULATING GAMMA-SECRETASE AND THEIR USE IN THE TREATMENT OF ALPHA BETA RELATED PATHOLOGIES, SUCH AS ALZHEIMER'S DISEASE | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010132015-A1 | NEW COMPOUNDS MODULATING GAMMA-SECRETASE AND THEIR USE IN THE TREATMENT OF ALPHA BETA RELATED PATHOLOGIES, SUCH AS ALZHEIMER'S DISEASE | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292210-A1 | Novel Compounds for A-Beta-Related Pathologies | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292210-A1 | Novel Compounds for A-Beta-Related Pathologies | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292210-A1 | Novel Compounds for A-Beta-Related Pathologies | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292210-A1 | Novel Compounds for A-Beta-Related Pathologies | BACE1, APP, BACE2 | SLC6A2 3599/4885SLC6A4 4528/4885SLC6A3 4185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.