Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.62 |
| ▸ | EGFR | P00533 | 11/20 | 0.62 |
| ▸ | CSF1R | P07333 | 6/20 | 0.60 |
| ▸ | KIT | P10721 | 6/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374394 | 0.90 | BRAF (0.63) | BRAFEGFRCSF1RKIT | |
| SCHEMBL374116 | 0.90 | BRAF (0.66) | BRAFEGFRCSF1RKIT | |
| SCHEMBL374756 | 0.88 | BRAF (0.63) | BRAFEGFRCSF1RKIT | |
| SCHEMBL374244 | 0.88 | BRAF (0.66) | BRAFEGFRCSF1RKIT | |
| SCHEMBL374512 | 0.87 | BRAF (0.61) | BRAFEGFRCSF1RKIT | |
| SCHEMBL374321 | 0.87 | BRAF (0.70) | BRAFEGFRCSF1RKIT | |
| SCHEMBL374349 | 0.85 | BRAF (0.67) | BRAFEGFRCSF1RKIT | |
| SCHEMBL374363 | 0.84 | BRAF (0.65) | BRAFEGFRCSF1RKIT | |
| SCHEMBL374152 | 0.82 | BRAF (0.42) | BRAFEGFRCSF1RKIT | |
| SCHEMBL15121678 | 0.82 | BRAF (0.56) | BRAFEGFRCSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409969-A1 | Pyrimidine urea derivatives as kinase inhibitors | Novartis AG (CH) | 2012-01-25 | — | — | EP | disclosed |