⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809949 | 0.62 | — | — | |
| SCHEMBL232624 | 0.61 | — | — | |
| SCHEMBL3603020 | 0.59 | — | — | |
| SCHEMBL30995351 | 0.58 | TDP1 (0.32) | — | |
| SCHEMBL9536676 | 0.57 | — | — | |
| SCHEMBL7377589 | 0.57 | — | — | |
| SCHEMBL7339315 | 0.57 | — | — | |
| SCHEMBL15040881 | 0.56 | — | — | |
| SCHEMBL15040682 | 0.56 | — | — | |
| SCHEMBL7248302 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150246888-A1 | ENOYL REDUCTASE INHIBITORS WITH ANTIBACTERIAL ACTIVITY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-09-03 | — | — | US | disclosed |
| EP-1491212-B1 | REMEDY FOR SLEEP DISTURBANCE | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-08-08 | — | — | EP | disclosed |
| US-20100143346-A1 | Treatment of Macular Degeneration | SUMMIT CORPORATION PLC (GB) | 2010-06-10 | — | — | US | disclosed |
| EP-2173331-A1 | TREATMENT OF MACULAR DEGENERATION | Summit (Cambridge) Ltd. (GB) | 2010-04-14 | — | — | EP | disclosed |
| WO-2008078095-A1 | TREATMENT OF MACULAR DEGENERATION | SUMMIT CORPORATION PLC (GB) | 2008-07-03 | — | — | WO | disclosed |
| US-20050090474-A1 | Methods and compositions for enhancing and inhibiting fertilization | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2005-04-28 | — | — | US | disclosed |
| WO-2003059373-A2 | COMPOSITIONS AND THEIR USE FOR ENHANCING AND INHIBITING FERTILIZATION | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2003-07-24 | — | — | WO | disclosed |
| EP-1222185-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001029029-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-04-26 | — | — | WO | disclosed |
| US-6077840-A | FOR TREATING OR PREVENTING PROGESTERONE-RELATED DISEASES, FOR HAVING AN ABORTION, OR FOR ORALLY PREVENTING CONCEPTION, BREAST CANCER, OVARIAN CANCER, HYSTEROMYOMA, ENDOMETRIOSIS, MENINGIOMA, MYELOMA, OSTEOPOROSIS | MEIJI SEIKA KAISHA, LTD. (JP) | 2000-06-20 | — | — | US | disclosed |
| CN-1240426-A | Novel tetrahydrobenzindolone derivatives | MEIJI SEIKA KAISHA (JP) | 2000-01-05 | — | — | CN | disclosed |