SCHEMBL232624

SCHEMBL232624

O=C1C=C2NC3C=CC=CC3C2C2C=C12

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3741830 0.61
SCHEMBL7248302 0.60
SCHEMBL7339315 0.54
SCHEMBL14274241 0.54
SCHEMBL6233873 0.53 ALDH1A1 (0.34)
SCHEMBL22809949 0.52
Hydrochloric Acid SCHEMBL7013829 0.52 ALDH1A1 (0.33)
SCHEMBL19207523 0.51 MAP3K14 (0.31)
SCHEMBL17035536 0.51 KDM4E (0.39)
SCHEMBL12871198 0.50

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10106852-B2 Mutated ACVR1 for diagnosis and treatment of Fibrodyplasia Ossificans Progressiva (FOP) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2018-10-23 US disclosed
US-9550817-B2 Men1 gene for diagnosis and treatment of diabetes THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2017-01-24 US disclosed
US-20150203918-A1 MUTATED ACVR1 FOR DIAGNOSIS AND TREATMENT OF FIBRODYPLASIA OSSIFICANS PROGRESSIVA (FOP) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2015-07-23 US disclosed
US-9018163-B2 Modulating PDX-1 with PCIF1, methods and uses thereof THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2015-04-28 US disclosed
US-8957012-B2 Gamma secretase inhibitor for treatment of herpesvirus infection THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2015-02-17 US disclosed
US-8895711-B2 Mutated ACVR1 for diagnosis and treatment of Fibrodyplasia Ossificans Progressiva (FOP) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2014-11-25 US disclosed
US-8642549-B2 OCL-2A3 compositions and uses thereof THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2014-02-04 US disclosed
US-8298545-B2 Anti-autoimmune antibodies for treatment of pemphigus THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2012-10-30 US disclosed
US-20120183508-A1 GAMMA SECRETASE INHIBITOR FOR TREATMENT OF HERPESVIRUS INFECTION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2012-07-19 US disclosed
US-8110557-B2 Gamma secretase inhibitor for treatment of herpesvirus infection THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2012-02-07 US disclosed
US-20090221493-A1 OCL-2A3 COMPOSITIONS AND USES THEREOF THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2009-09-03 US disclosed
US-20090181917-A1 MEN1 GENE FOR DIAGNOSIS AND TREATMENT OF DIABETES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2009-07-16 US disclosed
US-20090060881-A1 Gamma secretase inhibitor for treatment of herpesvirus infection THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2009-03-05 US disclosed
WO-2008109034-A2 MODULATING PDX-1 WITH PCIF1, METHODS AND USES THEREOF THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2008-09-12 WO disclosed
WO-2008097439-A2 ANTI-AUTOIMMUNE ANTIBODIES FOR TREATMENT OF PEMPHIGUS THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2008-08-14 WO disclosed
US-20080181882-A1 Neurgulin 1 (NRG1) - ErbB4 signaling as a target for the treatment of schizophrenia THE UNIVERSITY OF PENNSYLVANIA 2008-07-31 US disclosed
US-20080069827-A1 Therapy for herpes virus infection; blocking gene which is responsible for prevention apoptosis of neurons NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2008-03-20 US disclosed
WO-2007139970-A2 MEN1 GENE FOR DIAGNOSIS AND TREATMENT OF DIABETES THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2007-12-06 WO disclosed
WO-2007123896-A2 MUTATED ACVR1 FOR DIAGNOSIS AND TREATMENT OF FIBRODYPLASIA OSSIFICANS PROGRESSIVA (FOP) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2007-11-01 WO disclosed
US-20070071741-A1 OCL-2A3 compositions and uses thereof THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2007-03-29 US disclosed