Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 20/20 | 0.53 |
| ▸ | NR3C2 | P08235 | 12/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | PGR | P06401 | 8/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3755290 | 0.91 | NR3C1 (0.54) | NR3C1NR3C2CYP3A4PGR | |
| SCHEMBL676013 | 0.89 | NR3C1 (0.53) | NR3C1NR3C2CYP3A4PGR | |
| SCHEMBL3710020 | 0.89 | NR3C1 (0.52) | NR3C1NR3C2CYP3A4PGR | |
| SCHEMBL4447862 | 0.86 | NR3C1 (0.71) | NR3C1NR3C2CYP3A4PGR | |
| SCHEMBL3746290 | 0.86 | NR3C1 (0.52) | NR3C1NR3C2CYP3A4PGR | |
| SCHEMBL3688034 | 0.85 | NR3C1 (0.67) | NR3C1NR3C2PGR | |
| SCHEMBL6666787 | 0.81 | NR3C1 (0.51) | NR3C1NR3C2CYP3A4PGR | |
| SCHEMBL4556027 | 0.81 | NR3C1 (0.54) | NR3C1NR3C2CYP3A4PGR | |
| SCHEMBL4556423 | 0.81 | NR3C1 (0.52) | NR3C1NR3C2PGR | |
| SCHEMBL292944 | 0.80 | NR3C1 (0.77) | NR3C1NR3C2CYP3A4PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190431-A2 | COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST FOR TREATING OR CONTROLLING ANTERIOR-SEGMENT INFLAMMATION | Bausch & Lomb Incorporated (US) | 2010-06-02 | — | — | EP | disclosed |
| EP-2056799-A2 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING GLAUCOMA OR PROGRESSION THEREOF | Bausch & Lomb Incorporated (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2009023471-A2 | COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST FOR TREATING OR CONTROLLING ANTERIOR-SEGMENT INFLAMMATION | BAUSCH & LOMB INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |
| WO-2008027796-A2 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING GLAUCOMA OR PROGRESSION THEREOF | BAUSCH & LOMB INCORPORATED (US) | 2008-03-06 | — | — | WO | disclosed |