Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | PDE9A | O76083 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MAP2 | P11137 | 1/20 | 0.51 |
| ▸ | PADI4 | Q9UM07 | 8/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28049812 | 0.90 | KDM4E (0.60) | KDM4ETDP1MAPTALDH1A1HPGD | |
| SCHEMBL7811680 | 0.87 | KDM4E (0.70) | KDM4ETDP1MAPTALDH1A1HPGD | |
| SCHEMBL28040025 | 0.86 | KDM4E (0.56) | KDM4ETDP1MAPTALDH1A1HPGD | |
| SCHEMBL14796674 | 0.86 | KDM4E (0.60) | KDM4ETDP1MAPTALDH1A1HPGD | |
| SCHEMBL2805779 | 0.82 | KDM4E (1.00) | KDM4ETDP1MAPTALDH1A1HPGD | |
| SCHEMBL29415434 | 0.82 | KDM4E (1.00) | KDM4ETDP1MAPTALDH1A1HPGD | |
| SCHEMBL8925921 | 0.82 | KDM4E (0.49) | KDM4ETDP1MAPTALDH1A1HPGD | |
| SCHEMBL8924448 | 0.82 | KDM4E (0.59) | KDM4EALDH1A1HPGDLMNATSHR | |
| SCHEMBL17559719 | 0.80 | MEN1 (0.65) | KDM4ETDP1MAPTALDH1A1HPGD | |
| SCHEMBL28132803 | 0.80 | MAPT (0.71) | KDM4ETDP1MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181193-B2 | Indenoquinolone compound, preparation method and use thereof | SECOND MILITARY MEDICAL UNIVERSITY, PLA (CN) | 2015-11-10 | — | — | US | disclosed |
| US-20130102598-A1 | INDENOQUINOLONE COMPOUND, PREPARATION METHOD AND USE THEREOF | SECOND MILITARY MEDICAL UNIVERSITY, PLA (CN) | 2013-04-25 | — | — | US | disclosed |
| US-7829567-B2 | Imino-indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2010-11-09 | — | — | US | disclosed |
| US-7829567-B2 | Imino-indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2010-11-09 | — | — | US | disclosed |
| US-7829567-B2 | Imino-indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2010-11-09 | — | — | US | disclosed |
| US-20090111987-A1 | Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2009-04-30 | — | — | US | disclosed |
| US-20090111987-A1 | Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2009-04-30 | — | — | US | disclosed |
| US-20090111987-A1 | Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2009-04-30 | — | — | US | disclosed |
| US-6114349-A | Substituted quinoline derivatives with antiviral action | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102598-A1 | INDENOQUINOLONE COMPOUND, PREPARATION METHOD AND USE THEREOF | TOP1, TOP2A, TOP2B | KDM4E 2199/4885TDP1 428/4885MAPT 3771/4885 |
| US-20090111987-A1 | Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same | IMPA1, IMPDH1, IPO5 | KDM4E 1726/4885TDP1 2258/4885MAPT 2085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.