Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 6/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 6/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.36 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3735555 | 0.87 | PIM1 (0.48) | PIM1KCNQ3KCNQ2SRCKDM4E | |
| SCHEMBL3733165 | 0.82 | KCNQ3 (0.44) | PIM1KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL3741070 | 0.82 | PIM1 (0.45) | PIM1KCNQ3KCNQ2SRCKDM4E | |
| SCHEMBL3737701 | 0.81 | PIM1 (0.44) | PIM1SRCKDM4EPOLBKMT2A | |
| SCHEMBL3737713 | 0.80 | KCNN4 (0.35) | KCNQ3KCNQ2KCNE1KCNQ1HDAC1 | |
| SCHEMBL3730107 | 0.78 | PIM1 (0.42) | PIM1KDM4EPOLBKMT2ACYP1A2 | |
| SCHEMBL3730695 | 0.76 | GPR84 (0.47) | PIM1KDM4EPOLBKMT2AALDH1A1 | |
| SCHEMBL3735346 | 0.75 | PIM1 (0.49) | PIM1KCNQ3KCNQ2SRCKDM4E | |
| SCHEMBL3740566 | 0.74 | PIM1 (0.48) | PIM1KCNQ3KCNQ2SRCKDM4E | |
| SCHEMBL3730053 | 0.74 | PIM1 (0.47) | PIM1SRCKDM4EPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-B1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-12-12 | — | — | EP | disclosed |
| US-7829563-B2 | Aminoamides as orexin antagonists | HOFFMANN-LA ROCHE INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HCRTR1, HCRTR2, HRH3 | PIM1 4785/4885KCNQ3 1664/4885KCNQ2 2251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.