Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GPR6 | P46095 | 15/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3746292 | 1.00 | TLR8 (0.41) | TLR8TLR7GRM5GPR6OGA | |
| SCHEMBL3665959 | 0.86 | TLR8 (0.49) | TLR8TLR7GPR6NPC1RAB9A | |
| SCHEMBL3670942 | 0.86 | TLR8 (0.42) | TLR8TLR7GRM5GPR6OGA | |
| SCHEMBL3670944 | 0.86 | TLR8 (0.42) | TLR8TLR7GRM5GPR6OGA | |
| SCHEMBL3665961 | 0.86 | TLR8 (0.49) | TLR8TLR7GPR6NPC1RAB9A | |
| SCHEMBL3759005 | 0.82 | GRM5 (0.47) | TLR8TLR7GRM5OGANPC1 | |
| SCHEMBL3665906 | 0.81 | HRH3 (0.49) | TLR8TLR7GRM5OGANPC1 | |
| SCHEMBL3664942 | 0.81 | HRH3 (0.49) | TLR8TLR7GRM5OGANPC1 | |
| SCHEMBL3664945 | 0.81 | HRH3 (0.49) | TLR8TLR7GRM5OGANPC1 | |
| SCHEMBL3665904 | 0.81 | HRH3 (0.49) | TLR8TLR7GRM5OGANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292188-A1 | Compounds Comprising A Cyclobutoxy Group | UCB PHARMA S.A. (BE) | 2010-11-18 | — | — | US | claimed |
| US-20100292188-A1 | Compounds Comprising A Cyclobutoxy Group | UCB PHARMA S.A. (BE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292188-A1 | Compounds Comprising A Cyclobutoxy Group | CYP11B2, CYP11B1, CYP4B1 | TLR8 4686/4885TLR7 3431/4885GRM5 2077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.