Tryptophan

Tryptophan

SCHEMBL3746456

CC(C)C[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

nearest known ligand 0.59

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.59
▸ MAPT P10636 3/20 0.59
▸ LMNA P02545 2/20 0.59
▸ TSHR P16473 2/20 0.59
▸ BLM P54132 2/20 0.59
▸ PMP22 Q01453 2/20 0.59
▸ KMT2A Q03164 2/20 0.59
▸ MEN1 O00255 1/20 0.59
▸ MPO P05164 1/20 0.59
▸ HIF1A Q16665 1/20 0.59
▸ APAF1 O14727 1/20 0.48
▸ POLB P06746 1/20 0.48
▸ RECQL P46063 1/20 0.48
▸ L3MBTL1 Q9Y468 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.47
▸ ECE1 P42892 6/20 0.46
▸ ERAP2 Q6P179 2/20 0.45
▸ IL1RN P18510 2/20 0.44
▸ ERAP1 Q9NZ08 1/20 0.44
▸ HTR1A P08908 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dl-Tryptophan SCHEMBL28827035 0.96 KDM4E (0.64) KDM4EMAPTLMNATSHRBLM
Dl-Tryptophan SCHEMBL29253127 0.91 KDM4E (0.71) KDM4EMAPTLMNATSHRBLM
Tryptophan SCHEMBL17503874 0.91 KDM4E (0.71) KDM4EMAPTLMNATSHRBLM
Tryptophan SCHEMBL7356323 0.90 KDM4E (0.73) KDM4EMAPTLMNATSHRBLM
Dl-Tryptophan SCHEMBL7356311 0.90 KDM4E (0.73) KDM4EMAPTLMNATSHRBLM
Dl-Tryptophan SCHEMBL10428526 0.89 KDM4E (0.65) KDM4EMAPTLMNATSHRBLM
Tryptophan SCHEMBL10428528 0.89 KDM4E (0.65) KDM4EMAPTLMNATSHRBLM
Tryptophan SCHEMBL6863186 0.89 KDM4E (0.74) KDM4EMAPTLMNATSHRBLM
Tryptophan SCHEMBL8366914 0.88 KDM4E (0.70) KDM4EMAPTLMNATSHRBLM
Dl-Tryptophan SCHEMBL8366911 0.88 KDM4E (0.70) KDM4EMAPTLMNATSHRBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2101804-B1 PRO-ANGIOGENIC PEPTIDES SUSAVION BIOSCIENCES INC (US) 2016-02-17 — — EP disclosed
US-7838497-B2 Pro-angiogenic peptides SUSAVION BIOSCIENCES, INC. (US) 2010-11-23 — — US disclosed
EP-2101804-A2 PRO-ANGIOGENIC PEPTIDES Susavion Biosciences, Inc. (US) 2009-09-23 — — EP disclosed
US-20080233081-A1 PRO-ANGIOGENIC PEPTIDES SUSAVION BIOSCIENCES, INC. (US) 2008-09-25 — — US disclosed
WO-2008076815-A2 PRO-ANGIOGENIC PEPTIDES SUSAVION BIOSCIENCES, INC. (US) 2008-06-26 — — WO disclosed
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