Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | BLM | P54132 | 2/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | MPO | P05164 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | APAF1 | O14727 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL8366911 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL7356311 | 0.98 | KDM4E (0.73) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL7356323 | 0.98 | KDM4E (0.73) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL9225875 | 0.97 | KDM4E (0.65) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL9225863 | 0.97 | KDM4E (0.65) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL28120361 | 0.96 | KDM4E (0.76) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27443674 | 0.95 | KDM4E (0.68) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL6268677 | 0.93 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL537140 | 0.93 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL5481922 | 0.93 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001579-A | SOLID SUPPORT OF A COMPOUND SYNTHESIZED BY A SERIES OF REACTIONS AND A NUMBER OF IDENTIFIERS, EACH WITH A TAG, ATTACHED TO SUPPORT BUT NOT THROUGH COMPOUND; THE COMBINATION OF TAGS RECORDS THE REACTION HISTORY; FOR SCREENING COMPOUNDS | THE TRUSTEES OF COLUMBIA UNIVERSITY (US) | 1999-12-14 | — | — | US | disclosed |
| US-5968736-A | ENCODED COMBINATORIAL CHEMISTRY BY REACTING SUPPORT WITH FIRST REAGENT UNDER FIRST CONDITIONS, ATTACHING AT LEAST TWO DIFFERENT NON-SEQUENCABLE TAGS, REPEATING REACTING AND ATTACHING STEPS | COLD SPRING HARBOR LABORATORY (US) | 1999-10-19 | — | — | US | disclosed |
| US-5789172-A | Methods of determining the structure of a compound encoded by identifiers having tags | TRUSTEES OF THE COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1998-08-04 | — | — | US | disclosed |
| US-5721099-A | Complex combinatorial chemical libraries encoded with tags | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1998-02-24 | — | — | US | disclosed |
| US-5565324-A | FOR IDENTIFICATION OF NON-OLIGOMERIC COMPOUND, USING SOLID SUPPORT | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1996-10-15 | — | — | US | disclosed |