Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 19/20 | 0.79 |
| ▸ | TACR2 | P21452 | 1/20 | 0.60 |
| ▸ | TACR1 | P25103 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3741235 | 1.00 | TACR3 (0.79) | TACR3TACR2TACR1 | |
| SCHEMBL3744886 | 0.89 | TACR3 (0.64) | TACR3 | |
| SCHEMBL3742058 | 0.89 | TACR3 (0.64) | TACR3 | |
| SCHEMBL3751174 | 0.89 | TACR3 (0.62) | TACR3 | |
| SCHEMBL3742048 | 0.89 | TACR3 (0.62) | TACR3 | |
| SCHEMBL2478814 | 0.89 | TACR3 (1.00) | TACR3TACR2TACR1 | |
| SCHEMBL2477088 | 0.89 | TACR3 (1.00) | TACR3TACR2TACR1 | |
| SCHEMBL2477608 | 0.88 | TACR3 (0.86) | TACR3TACR2TACR1 | |
| SCHEMBL2481027 | 0.88 | TACR3 (0.86) | TACR3TACR2TACR1 | |
| SCHEMBL6023186 | 0.87 | TACR3 (0.85) | TACR3TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7834008-B2 | neurokinin receptor 3 (NK3) antagonists; psychological disorders, inflammatory bowel disease, asthma, ischemia, Parkinson's disease; e.g. (1S,2R)-2-(4-Acetylamino-4-phenyl-piperidin-1-ylmethyl)-1-(3,4-dichlorophenyl)-cyclopropanecarboxylic acid, benzyl-methyl-amide | H. LUNDBECK A/S (DK) | 2010-11-16 | — | — | US | disclosed |
| US-20060281746-A1 | Cyclopropyl derivatives as nk3 receptor antagonists | H. LUNDBECK A/S (DK) | 2006-12-14 | — | — | US | disclosed |
| WO-2005016884-A9 | CYCLOPROPYL DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | LUNDBECK & CO AS H (DK) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281746-A1 | Cyclopropyl derivatives as nk3 receptor antagonists | TACR2, SLC6A3, TACR1 | TACR3 5/4885TACR2 1/4885TACR1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.