Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.66 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.61 |
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8172927 | 0.92 | ABCG2 (0.55) | ABCG2CYP1A1CYP1A2CYP1B1TNFRSF1A | |
| SCHEMBL3738143 | 0.92 | ABCG2 (0.55) | ABCG2CYP1A1CYP1A2CYP1B1TNFRSF1A | |
| SCHEMBL3733437 | 0.91 | ABCG2 (0.53) | ABCG2CYP1A1CYP1A2CYP1B1TNFRSF1A | |
| SCHEMBL3735031 | 0.91 | ABCG2 (0.53) | ABCG2CYP1A1CYP1A2CYP1B1TNFRSF1A | |
| SCHEMBL3748001 | 0.91 | ABCG2 (0.66) | ABCG2CYP1A1CYP1A2CYP1B1TNFRSF1A | |
| SCHEMBL3738142 | 0.83 | MEN1 (0.58) | ABCG2CYP1A1CYP1A2CYP1B1TNFRSF1A | |
| SCHEMBL3734081 | 0.82 | CYP1A1 (0.47) | CYP1A1CYP1B1MAPT | |
| SCHEMBL3735028 | 0.82 | CXCL12 (0.55) | ABCG2CYP1A1CYP1A2CYP1B1TNFRSF1A | |
| SCHEMBL3733434 | 0.82 | CXCL12 (0.55) | ABCG2CYP1A1CYP1A2CYP1B1TNFRSF1A | |
| SCHEMBL3735097 | 0.82 | ABCG2 (0.79) | ABCG2CYP1A1CYP1B1TNFRSF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-B1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-12-12 | — | — | EP | disclosed |
| US-7829563-B2 | Aminoamides as orexin antagonists | HOFFMANN-LA ROCHE INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HCRTR1, HCRTR2, HRH3 | ABCG2 3975/4885CYP1A1 1184/4885CYP1A2 1026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.