Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.49 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3733434 | 0.91 | CXCL12 (0.55) | ABCG2CYP1A1CYP1B1CYP1A2TNFRSF1A | |
| SCHEMBL3748003 | 0.91 | ABCG2 (0.66) | ABCG2CYP1A1CYP1B1CYP1A2TNFRSF1A | |
| SCHEMBL3735031 | 0.89 | ABCG2 (0.53) | ABCG2CYP1A1CYP1B1CYP1A2TNFRSF1A | |
| SCHEMBL3734081 | 0.87 | CYP1A1 (0.47) | CYP1A1CYP1B1MAPT | |
| SCHEMBL8172927 | 0.85 | ABCG2 (0.55) | ABCG2CYP1A1CYP1B1CYP1A2TNFRSF1A | |
| SCHEMBL3738143 | 0.85 | ABCG2 (0.55) | ABCG2CYP1A1CYP1B1CYP1A2TNFRSF1A | |
| SCHEMBL3735484 | 0.83 | PTGS2 (0.48) | CYP1A1CYP1B1CYP1A2TNFRSF1AMAPT | |
| SCHEMBL15807389 | 0.82 | CYP1A1 (0.67) | ABCG2CYP1A1CYP1B1TNFRSF1ACXCL12 | |
| SCHEMBL3738227 | 0.82 | PTGS2 (0.47) | CYP1A1CYP1B1CYP1A2CXCL12MAPT | |
| SCHEMBL3748001 | 0.82 | ABCG2 (0.66) | ABCG2CYP1A1CYP1B1CYP1A2TNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-B1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-12-12 | — | — | EP | disclosed |
| US-7829563-B2 | Aminoamides as orexin antagonists | HOFFMANN-LA ROCHE INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221166-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | HCRTR1, HCRTR2, HRH3 | ABCG2 3975/4885CYP1A1 1184/4885CYP1B1 976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.