Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| N-Methyl-N-Nitrosurea SCHEMBL38377 | 0.94 | — | — | |
| N-Methyl-N-Nitrosurea SCHEMBL28025247 | 0.94 | ALDH1A1 (0.39) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| N-Methyl-N-Nitrosurea SCHEMBL27452637 | 0.92 | — | — | |
| N-Methyl-N-Nitrosurea SCHEMBL27400389 | 0.92 | — | — | |
| N-Methyl-N-Nitrosurea SCHEMBL28057965 | 0.92 | ALDH1A1 (0.37) | ALDH1A1TP53LMNAALOX15BLM | |
| N-Methyl-N-Nitrosurea SCHEMBL28089372 | 0.92 | — | — | |
| N-Methyl-N-Nitrosurea SCHEMBL27465067 | 0.92 | — | — | |
| N-Methyl-N-Nitrosurea SCHEMBL27534649 | 0.92 | — | — | |
| N-Methyl-N-Nitrosurea SCHEMBL27654363 | 0.87 | F2 (0.35) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| N-Methyl-N-Nitrosurea SCHEMBL18660152 | 0.86 | FFAR3 (0.37) | ALDH1A1TP53LMNAALOX15BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001503-B1 | DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE | RHODE ISLAND HOSPITAL (US) | 2017-06-07 | — | — | EP | disclosed |
| EP-1817050-B1 | DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE | RHODE ISLAND HOSPITAL (US) | 2015-04-15 | — | — | EP | disclosed |
| CN-101102789-B | Diagnosis and treatment of Alzheimer's disease | RHODE ISLAND HOSPITAL | 2012-05-30 | — | — | CN | disclosed |
| US-7833513-B2 | Treatment of Alzheimer's Disease | RHODE ISLAND HOSPITAL (US) | 2010-11-16 | — | — | US | disclosed |
| EP-1817050-A4 | DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE | RHODE ISLAND HOSPITAL (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-2001503-A2 | DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE | RHODE ISLAND HOSPITAL (US) | 2008-12-17 | — | — | EP | disclosed |
| CN-101102789-A | Diagnosis and treatment of Alzheimer's disease | RHODE ISLAND HOSPITAL (US) | 2008-01-09 | — | — | CN | disclosed |
| WO-2007123723-A2 | DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE | RHODE ISLAND HOSPITAL (US) | 2007-11-01 | — | — | WO | disclosed |
| EP-1817050-A2 | DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE | RHODE ISLAND HOSPITAL (US) | 2007-08-15 | — | — | EP | disclosed |
| US-20070042437-A1 | Diagnosis and treatment of Alzheimer's Disease | RHODE ISLAND HOSPITAL (US) | 2007-02-22 | — | — | US | disclosed |
| WO-2006060753-A2 | DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE | RHODE ISLAND HOSPITAL (US) | 2006-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070042437-A1 | Diagnosis and treatment of Alzheimer's Disease | IGF1R, IAPP, APP | ALDH1A1 2685/4885F2 3977/4885PRSS1 1935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.