Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.58 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | TYR | P14679 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3748350 | 1.00 | ALDH1A1 (0.59) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL2831943 | 1.00 | ALDH1A1 (0.59) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL8062621 | 1.00 | ALDH1A1 (0.59) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL3748439 | 1.00 | ALDH1A1 (0.59) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL2473707 | 0.84 | CA12 (0.70) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL1564066 | 0.84 | CA12 (0.70) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL1972599 | 0.84 | CA12 (0.70) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL2829725 | 0.83 | HTT (0.66) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL2829726 | 0.83 | HTT (0.66) | ALDH1A1HTTPOLBMEN1KMT2A | |
| SCHEMBL30493211 | 0.82 | ALDH1A1 (0.83) | ALDH1A1HTTPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450525-B2 | Histone deacetylase inhibitors | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2013-05-28 | — | — | US | disclosed |
| US-20100291003-A1 | HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100291003-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HDAC5 | ALDH1A1 473/4885HTT 817/4885POLB 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.