Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.59 |
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637336 | 0.77 | ADORA2A (0.60) | ADORA2AMAOBADORA3ADORA2BADORA1 | |
| SCHEMBL3748563 | 0.75 | MAOB (0.61) | ADORA2AMAOBADORA3ADORA2BADORA1 | |
| Istradefylline SCHEMBL633263 | 0.74 | ADORA2A (1.00) | ADORA2AMAOBADORA3ADORA2BADORA1 | |
| Istradefylline SCHEMBL29471410 | 0.74 | ADORA2A (1.00) | ADORA2AMAOBADORA3ADORA2BADORA1 | |
| Istradefylline SCHEMBL5967914 | 0.74 | ADORA2A (1.00) | ADORA2AMAOBADORA3ADORA2BADORA1 | |
| Istradefylline SCHEMBL633262 | 0.74 | ADORA2A (1.00) | ADORA2AMAOBADORA3ADORA2BADORA1 | |
| Istradefylline SCHEMBL30358491 | 0.74 | ADORA2A (1.00) | ADORA2AMAOBADORA3ADORA2BADORA1 | |
| SCHEMBL28126790 | 0.74 | ADORA2A (0.58) | ADORA2AMAOBADORA3ADORA2BADORA1 | |
| SCHEMBL14546946 | 0.72 | ADORA2A (0.85) | ADORA2AMAOBADORA3ADORA2BADORA1 | |
| SCHEMBL14541714 | 0.71 | ADORA2A (0.92) | ADORA2AMAOBADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005079250-A2 | PURINES ARE SELF-RENEWAL SIGNALS FOR NEURAL STEM CELLS, AND PURINE RECEPTOR ANTAGONISTS PROMOTE NEURONAL AND GLIAL DIFFERENTIATION THEREFROM | CORNELL RESEARCH FOUNDATION, INC. (US) | 2005-09-01 | — | — | WO | claimed |
| US-20050181503-A1 | Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-08-18 | — | — | US | claimed |
| US-7829332-B2 | Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom | CORNELL RESEARCH FOUNDATION, INC. (US) | 2010-11-09 | — | — | US | disclosed |
| WO-2005079250-A2 | PURINES ARE SELF-RENEWAL SIGNALS FOR NEURAL STEM CELLS, AND PURINE RECEPTOR ANTAGONISTS PROMOTE NEURONAL AND GLIAL DIFFERENTIATION THEREFROM | CORNELL RESEARCH FOUNDATION, INC. (US) | 2005-09-01 | — | — | WO | disclosed |
| US-20050181503-A1 | Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-08-18 | — | — | US | disclosed |