Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ziprasidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 13/20 | 0.98 |
| ▸ | DRD2 known ✓ | P14416 | 11/20 | 0.98 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.98 |
| ▸ | HTR1A | P08908 | 8/20 | 0.98 |
| ▸ | HTR7 | P34969 | 3/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | HTR6 | P50406 | 2/20 | 0.98 |
| ▸ | MTOR | P42345 | 1/20 | 0.98 |
| ▸ | RAB9A | P51151 | 1/20 | 0.98 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.98 |
| ▸ | HTR3B | O95264 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | PGR | P06401 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.98 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.98 |
| ▸ | MAPT | P10636 | 1/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.98 |
| ▸ | GOT1 | P17174 | 1/20 | 0.98 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ziprasidone SCHEMBL27601333 | 1.00 | HTR2A (0.98) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| Ziprasidone SCHEMBL27825050 | 1.00 | HTR2A (0.98) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| Ziprasidone SCHEMBL4914143 | 1.00 | HTR2A (0.98) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| Ziprasidone SCHEMBL2978308 | 0.99 | KCNH2 (1.00) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| Ziprasidone SCHEMBL3136309 | 0.99 | KCNH2 (0.97) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| Ziprasidone SCHEMBL2978306 | 0.99 | KCNH2 (1.00) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| Ziprasidone SCHEMBL122875 | 0.99 | KCNH2 (1.00) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| Ziprasidone SCHEMBL930539 | 0.99 | KCNH2 (1.00) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| Ziprasidone SCHEMBL3148898 | 0.99 | KCNH2 (0.97) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| Ziprasidone SCHEMBL10324884 | 0.99 | KCNH2 (1.00) | HTR2ADRD2HTR1AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109939073-A | Ziprasidone HCl oral disintegrating tablet and preparation method thereof | 万全万特制药（厦门）有限公司 | 2019-06-28 | — | — | CN | disclosed |
| WO-2016191316-A1 | MODULATION OF DRUG-INDUCED CARDIOTOXICITY | STEM CELL THERANOSTICS, INC. (US) | 2016-12-01 | — | — | WO | disclosed |
| CN-102234273-B | Ziprasidone mesylate semihydrate and preparation method thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2015-08-05 | — | — | CN | disclosed |
| EP-2197446-A4 | PREPARATION OF ZIPRASIDONE HYDROCHLORIDE MONOHYDRATE | REDDYS LAB LTD DR (IN) | 2012-01-25 | — | — | EP | disclosed |
| CN-102234273-A | Ziprasidone mesylate semihydrate and preparation method thereof | SHANGHAI INST PHARM INDUSTRY | 2011-11-09 | — | — | CN | disclosed |
| EP-2197446-A2 | PREPARATION OF ZIPRASIDONE HYDROCHLORIDE MONOHYDRATE | Dr. Reddy's Laboratories Ltd. (IN) | 2010-06-23 | — | — | EP | disclosed |
| EP-2197446-A2 | PREPARATION OF ZIPRASIDONE HYDROCHLORIDE MONOHYDRATE | Dr. Reddy's Laboratories Ltd. (IN) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009032558-A3 | PREPARATION OF ZIPRASIDONE HYDROCHLORIDE MONOHYDRATE | REDDYS LAB LTD DR (IN) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009032558-A3 | PREPARATION OF ZIPRASIDONE HYDROCHLORIDE MONOHYDRATE | REDDYS LAB LTD DR (IN) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009032558-A2 | PREPARATION OF ZIPRASIDONE HYDROCHLORIDE MONOHYDRATE | DR. REDDY'S LABORATORIES LTD. (IN) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032558-A2 | PREPARATION OF ZIPRASIDONE HYDROCHLORIDE MONOHYDRATE | DR. REDDY'S LABORATORIES LTD. (IN) | 2009-03-12 | — | — | WO | disclosed |
| WO-2007126322-A1 | A METHOD FOR OBTAINING A PHARMACEUTICAL COMPOSITION COMPRISING AN ACTIVE AGENT ZIPRASIDONE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | PLIVAKRAKÓW, ZAKLADY FARMACEUTYCZNE S.A. (PL) | 2007-11-08 | — | — | WO | disclosed |
| WO-2007102038-A1 | ZIPRASIDONE FORMULATIONS | WOCKHARDT LIMITED (IN) | 2007-09-13 | — | — | WO | disclosed |
| CN-1898236-A | Processes for preparation of ziprasidone | TEVA PHARMA (IL) | 2007-01-17 | — | — | CN | disclosed |