Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | POLR1A | O95602 | 1/20 | 0.44 |
| ▸ | ECE1 | P42892 | 1/20 | 0.44 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31237300 | 1.00 | HTT (0.50) | HTTPOLBAOX1RAD52SMN1; SMN2 | |
| SCHEMBL26757977 | 0.80 | HTT (0.56) | HTTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4371080 | 0.80 | RAD52 (0.67) | HTTAOX1RAD52SMN1; SMN2KDM4E | |
| SCHEMBL31203036 | 0.79 | HTT (0.67) | HTTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL14574206 | 0.78 | HTT (0.49) | HTTPOLBSMN1; SMN2KDM4EMAPT | |
| SCHEMBL5713303 | 0.78 | HTT (0.54) | HTTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7460757 | 0.78 | CYP1A2 (0.64) | HTTPOLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2748233 | 0.78 | ALDH1A1 (0.67) | HTTPOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL18770223 | 0.77 | HTT (0.53) | HTTPOLBSMN1; SMN2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10526031 | 0.77 | RAD52 (0.56) | HTTPOLBAOX1RAD52SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9878984-B2 | Anti-cancer compounds | NORTHWESTERN UNIVERSITY (US) | 2018-01-30 | — | — | US | disclosed |
| US-20140378503-A1 | ANTI-CANCER COMPOUNDS | NORTHWESTERN UNIVERSITY | 2014-12-25 | — | — | US | disclosed |
| US-8829025-B2 | Anti-cancer compounds | NORTHWESTERN UNIVERSITY (US) | 2014-09-09 | — | — | US | disclosed |
| US-20130225634-A1 | ANTI-CANCER COMPOUNDS | NORTHWESTERN UNIVERSITY (US) | 2013-08-29 | — | — | US | disclosed |
| US-8420665-B2 | Anti-cancer compounds | NORTHWESTERN UNIVERSITY (US) | 2013-04-16 | — | — | US | disclosed |
| US-20100303719-A1 | ANTI-CANCER COMPOUNDS | NORTHWESTERN UNIVERSITY (US) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378503-A1 | ANTI-CANCER COMPOUNDS | TP53, MKI67, MYC | HTT 2573/4885POLB 1443/4885AOX1 2194/4885 |
| US-20100303719-A1 | ANTI-CANCER COMPOUNDS | TP53, MKI67, MYC | HTT 2573/4885POLB 1443/4885AOX1 2194/4885 |
| US-20130225634-A1 | ANTI-CANCER COMPOUNDS | TP53, MKI67, MYC | HTT 2573/4885POLB 1443/4885AOX1 2194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.