Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757535 | 0.85 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2LMNAKMT2APOLB | |
| SCHEMBL3761284 | 0.78 | HTT (0.58) | ALDH1A1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL3754218 | 0.77 | ALDH1A1 (0.66) | ALDH1A1KDM4ESMN1; SMN2LMNAKMT2A | |
| SCHEMBL3755185 | 0.77 | ALDH1A1 (0.68) | ALDH1A1KDM4ESMN1; SMN2LMNAKMT2A | |
| SCHEMBL3757356 | 0.76 | ALDH1A1 (0.67) | ALDH1A1KDM4ESMN1; SMN2LMNAKMT2A | |
| SCHEMBL3755792 | 0.76 | KMT2A (0.44) | P2RX7ALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL3761389 | 0.76 | GLA (0.44) | P2RX7ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL3791796 | 0.73 | HTT (0.53) | ALDH1A1KDM4ESMN1; SMN2LMNAKMT2A | |
| SCHEMBL3760532 | 0.73 | ALDH1A1 (0.57) | P2RX7ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL3755149 | 0.69 | GLA (0.54) | P2RX7ALDH1A1KDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138828-A2 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | claimed |
| US-20100305109-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | claimed |
| US-8962639-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2015-02-24 | — | — | US | disclosed |
| WO-2010138828-A2 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |
| US-20100305109-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305109-A1 | POTASSIUM CHANNEL MODULATORS | KCNQ1, KCNQ2, KCNJ2 | TGM2 3857/4885P2RX7 172/4885ALDH1A1 1031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.