Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 20/20 | 0.60 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3750004 | 1.00 | MMP13 (0.60) | MMP13SLC22A8MMP3 | |
| SCHEMBL3806702 | 0.92 | MMP13 (0.62) | MMP13SLC22A8MMP3 | |
| SCHEMBL3806698 | 0.92 | MMP13 (0.62) | MMP13SLC22A8MMP3 | |
| SCHEMBL3798394 | 0.90 | MMP13 (0.68) | MMP13SLC22A8MMP3 | |
| SCHEMBL8068202 | 0.90 | MMP13 (0.66) | MMP13SLC22A8MMP3 | |
| SCHEMBL3808968 | 0.90 | MMP13 (0.66) | MMP13SLC22A8MMP3 | |
| SCHEMBL3798392 | 0.90 | MMP13 (0.68) | MMP13SLC22A8MMP3 | |
| SCHEMBL3808963 | 0.90 | MMP13 (0.66) | MMP13SLC22A8MMP3 | |
| SCHEMBL3809990 | 0.89 | MMP13 (0.57) | MMP13SLC22A8MMP3 | |
| SCHEMBL3814040 | 0.89 | MMP13 (0.57) | MMP13SLC22A8MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185537-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |