Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 8/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 6/20 | 0.49 |
| ▸ | CCND2 | P30279 | 4/20 | 0.49 |
| ▸ | CCND3 | P30281 | 4/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757216 | 0.96 | CDK4 (0.48) | CDK4AURKAMAPK1MAPTTP53 | |
| SCHEMBL4392941 | 0.80 | FLT3 (0.47) | CDK4AURKAMAPK1MAPTTP53 | |
| SCHEMBL12085363 | 0.78 | CDK4 (0.65) | CDK4AURKAMAPK1MAPTTP53 | |
| SCHEMBL3754995 | 0.77 | MAPK1 (0.47) | CDK4AURKAMAPK1MAPTTP53 | |
| SCHEMBL1355413 | 0.77 | CDK4 (0.72) | CDK4AURKACCND1CCND2CCND3 | |
| SCHEMBL12639296 | 0.77 | CDK4 (0.72) | CDK4AURKACCND1CCND2CCND3 | |
| SCHEMBL29576169 | 0.76 | MAPK1 (0.53) | MAPK1MAPTTP53SYKSMN1; SMN2 | |
| SCHEMBL3748201 | 0.76 | JAK3 (0.47) | CDK4AURKAMAPK1MAPTTP53 | |
| SCHEMBL3751156 | 0.76 | MAPT (0.46) | CDK4AURKAMAPK1MAPTTP53 | |
| SCHEMBL24243309 | 0.74 | TTK (0.67) | AURKAMAPK1MAPTTP53TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298557-A1 | PYRAZOLOPYRIMIDINE COMPOUND | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-11-25 | — | — | US | disclosed |
| EP-2123654-A1 | PYRAZOLOPYRIMIDINE COMPOUND | Taisho Pharmaceutical Co. Ltd. (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298557-A1 | PYRAZOLOPYRIMIDINE COMPOUND | SYK, LCK, FYN | CDK4 1029/4885AURKA 321/4885MAPK1 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.