Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.41 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757216 | 0.85 | CDK4 (0.48) | FLT3MAPTMAPK1MEN1KMT2A | |
| SCHEMBL3750895 | 0.80 | CDK4 (0.51) | MAPTMAPK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1591330 | 0.72 | FLT3 (0.47) | FLT3MAPTMAPK1KDM4EMEN1 | |
| SCHEMBL30465997 | 0.70 | HRH3 (0.43) | MTORPIK3CAPIK3CGMAPK14CSNK1G1 | |
| SCHEMBL31236237 | 0.68 | HTR2C (0.49) | HTR2CMEN1KMT2A | |
| SCHEMBL26102644 | 0.68 | PDE1C (0.46) | — | |
| SCHEMBL30782433 | 0.68 | ABL1 (0.56) | MAPTKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3749814 | 0.67 | JAK3 (0.45) | FLT3MAPTMAPK1MERTKTP53 | |
| SCHEMBL12639296 | 0.67 | CDK4 (0.72) | CDK4AURKACCNB2CCNE2CDK1 | |
| SCHEMBL1355413 | 0.67 | CDK4 (0.72) | CDK4AURKACCNB2CCNE2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2123654-A1 | PYRAZOLOPYRIMIDINE COMPOUND | Taisho Pharmaceutical Co. Ltd. (JP) | 2009-11-25 | — | — | EP | disclosed |