Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.56 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.56 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.56 |
| ▸ | HINT1 | P49773 | 3/20 | 0.50 |
| ▸ | TYMP | P19971 | 1/20 | 0.50 |
| ▸ | NT5E | P21589 | 2/20 | 0.48 |
| ▸ | POLA1 | P09884 | 1/20 | 0.47 |
| ▸ | PNP | P00491 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL766594 | 0.91 | POLB (0.63) | POLBP2RY2P2RY4P2RY6HINT1 | |
| SCHEMBL16359949 | 0.89 | POLB (0.70) | POLBP2RY2P2RY4P2RY6HINT1 | |
| SCHEMBL338650 | 0.89 | POLB (0.70) | POLBP2RY2P2RY4P2RY6HINT1 | |
| SCHEMBL367384 | 0.89 | POLB (0.65) | POLBP2RY2P2RY4P2RY6HINT1 | |
| SCHEMBL8057804 | 0.89 | POLB (0.65) | POLBP2RY2P2RY4P2RY6HINT1 | |
| SCHEMBL8490891 | 0.88 | POLB (0.71) | POLBP2RY2P2RY4P2RY6HINT1 | |
| SCHEMBL442294 | 0.88 | POLB (0.71) | POLBP2RY2P2RY4P2RY6HINT1 | |
| SCHEMBL20209337 | 0.88 | POLB (0.53) | POLBP2RY2P2RY4P2RY6HINT1 | |
| SCHEMBL27277379 | 0.88 | POLB (0.53) | POLBP2RY2P2RY4P2RY6HINT1 | |
| SCHEMBL3744960 | 0.88 | POLB (0.68) | POLBP2RY2P2RY4P2RY6HINT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767842-B1 | METHODS OF SCREENING FOR NUCLEOSIDE ANALOGS THAT ARE INCORPORATED BY HIV REVERSE TRANSCRIPTASE AND CAUSE INCORRECT BASE PAIRING | UNIV WASHINGTON (US) | 2000-09-27 | — | — | EP | claimed |
| EP-1004675-A2 | Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing | DARWIN MOLECULAR CORPORATION (US) | 2000-05-31 | — | — | EP | claimed |
| US-7838637-B2 | Polyclonal immunoglobulin for use in diagnosis, prevention and treatment of infection, cell proliferative, blood, autoimmune and nervous system disorders | AFFITECH RESEARCH AS (NO) | 2010-11-23 | — | — | US | disclosed |
| US-20090326206-A1 | Single-chain Multiple Antigen-binding Molecule, Its Preparation and Use | AFFITECH RESEARCH AS (NO) | 2009-12-31 | — | — | US | disclosed |
| US-20050004352-A1 | Single-chain multiple antigen-binding molecule, its preparation and use | AFFITECH RESEARCH AS (NO) | 2005-01-06 | — | — | US | disclosed |
| US-20030054409-A1 | Novel complex-forming proteins | JEROME VALERIE (DE) | 2003-03-20 | — | — | US | disclosed |
| EP-0767842-B1 | METHODS OF SCREENING FOR NUCLEOSIDE ANALOGS THAT ARE INCORPORATED BY HIV REVERSE TRANSCRIPTASE AND CAUSE INCORRECT BASE PAIRING | UNIV WASHINGTON (US) | 2000-09-27 | — | — | EP | disclosed |
| EP-1004675-A2 | Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing | DARWIN MOLECULAR CORPORATION (US) | 2000-05-31 | — | — | EP | disclosed |
| EP-0846772-A1 | Multifunctional ligand system for cell-specific transfer of nucleic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-06-10 | — | — | EP | disclosed |
| EP-0767842-A1 | METHODS OF SCREENING FOR NUCLEOSIDE ANALOGS THAT ARE INCORPORATED BY HIV REVERSE TRANSCRIPTASE AND CAUSE INCORRECT BASE PAIRING | DARWIN MOLECULAR CORPORATION (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000797-A1 | METHODS OF SCREENING FOR NUCLEOSIDE ANALOGS THAT ARE INCORPORATED BY HIV REVERSE TRANSCRIPTASE AND CAUSE INCORRECT BASE PAIRING | DARWIN MOLECULAR CORP (US) | 1996-01-11 | — | — | WO | disclosed |