SCHEMBL338650

SCHEMBL338650

COC[C@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)nc32)C[C@@H]1O

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.70
P2RY2 P41231 1/20 0.58
P2RY4 P51582 1/20 0.58
P2RY6 Q15077 1/20 0.58
HINT1 P49773 3/20 0.52
TYMP P19971 1/20 0.52
NT5E P21589 2/20 0.50
POLA1 P09884 1/20 0.49
PNP P00491 1/20 0.49
LMNA P02545 1/20 0.49
TP53 P04637 1/20 0.49
HTT P42858 1/20 0.49
PDE4D Q08499 1/20 0.49
PDE3A Q14432 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49
HPGD P15428 1/20 0.48
FUT5 Q11128 1/20 0.47
GSK3A P49840 1/20 0.47
RPS6KA3 P51812 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16359949 1.00 POLB (0.70) POLBP2RY2P2RY4P2RY6HINT1
SCHEMBL442294 0.91 POLB (0.71) POLBP2RY2P2RY4P2RY6HINT1
SCHEMBL8490891 0.91 POLB (0.71) POLBP2RY2P2RY4P2RY6HINT1
SCHEMBL3744960 0.90 POLB (0.68) POLBP2RY2P2RY4P2RY6HINT1
SCHEMBL15012843 0.90 POLB (0.70) POLBP2RY2P2RY4P2RY6HINT1
SCHEMBL15798769 0.90 POLB (0.70) POLBP2RY2P2RY4P2RY6HINT1
SCHEMBL3751858 0.89 POLB (0.67) POLBP2RY2P2RY4P2RY6HINT1
SCHEMBL8622463 0.89 POLB (0.67) POLBP2RY2P2RY4P2RY6HINT1
SCHEMBL8622459 0.89 POLB (0.67) POLBP2RY2P2RY4P2RY6HINT1
SCHEMBL27984215 0.89 POLB (0.64) POLBP2RY2P2RY4P2RY6HINT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 559 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250263678-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA REJUVENATION TECHNOLOGIES, INC. (US) 2025-08-21 US claimed
US-20230099822-A1 MR1 LIGANDS AND PHARMACEUTICAL COMPOSITIONS FOR IMMUNOMODULATION UNIVERSITÄT BASEL (CH) 2023-03-30 US claimed
EP-4090969-A1 MR1 LIGANDS AND PHARMACEUTICAL COMPOSITIONS FOR IMMUNOMODULATION Universität Basel (CH) 2022-11-23 EP claimed
EP-2010659-A2 KITS AND METHODS FOR GENERATING 5' CAPPED RNA Epicentre Technologies (US) 2009-01-07 EP claimed
WO-2007120863-A2 KITS AND METHODS FOR GENERATING 5' CAPPED RNA EPICENTRE TECHNOLOGIES (US) 2007-10-25 WO claimed
EP-0767842-B1 METHODS OF SCREENING FOR NUCLEOSIDE ANALOGS THAT ARE INCORPORATED BY HIV REVERSE TRANSCRIPTASE AND CAUSE INCORRECT BASE PAIRING UNIV WASHINGTON (US) 2000-09-27 EP claimed
EP-1004675-A2 Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing DARWIN MOLECULAR CORPORATION (US) 2000-05-31 EP claimed
EP-0767842-A1 METHODS OF SCREENING FOR NUCLEOSIDE ANALOGS THAT ARE INCORPORATED BY HIV REVERSE TRANSCRIPTASE AND CAUSE INCORRECT BASE PAIRING DARWIN MOLECULAR CORPORATION (US) 1997-04-16 EP claimed
WO-1996000797-A1 METHODS OF SCREENING FOR NUCLEOSIDE ANALOGS THAT ARE INCORPORATED BY HIV REVERSE TRANSCRIPTASE AND CAUSE INCORRECT BASE PAIRING DARWIN MOLECULAR CORP (US) 1996-01-11 WO claimed
JP-5273209-A None JP disclosed
US-12584168-B2 Sample preparation method OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2026-03-24 US disclosed
US-12559748-B2 Compositions and methods for the treatment of hemoglobinopathies NOVARTIS AG (CH) 2026-02-24 US disclosed
US-20260022377-A1 POLYNUCLEOTIDE COMPOSITIONS AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASES APTAH BIO INC (US) 2026-01-22 US disclosed
US-20250313889-A1 SAMPLE PREPARATION METHOD OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2025-10-09 US disclosed
EP-0700442-A1 IMMORTALIZED HUMAN CELL LINES CONTAINING EXOGENOUS CYTOCHROME P450 GENES THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1996-03-13 EP disclosed
WO-1996000797-A1 METHODS OF SCREENING FOR NUCLEOSIDE ANALOGS THAT ARE INCORPORATED BY HIV REVERSE TRANSCRIPTASE AND CAUSE INCORRECT BASE PAIRING DARWIN MOLECULAR CORP (US) 1996-01-11 WO disclosed
EP-0625985-A1 METHOD AND RING-OPENED PURINE COMPOUNDS FOR LABELING POLYNUCLEOTIDES. UNIV MIAMI (US) 1994-11-30 EP disclosed
WO-1994026905-A1 IMMORTALIZED HUMAN CELL LINES CONTAINING EXOGENOUS CYTOCHROME P450 GENES THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1994-11-24 WO disclosed
JP-H05273209-A DNA DETECTING KIT TAKARA SHUZO CO LTD 1993-10-22 JP disclosed
WO-1993011146-A1 METHOD AND RING-OPENED PURINE COMPOUNDS FOR LABELING POLYNUCLEOTIDES UNIVERSITY OF MIAMI (US) 1993-06-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12584168-B2 Sample preparation method POLN, POLRMT, POLM POLB 4/4885P2RY2 181/4885P2RY4 141/4885
US-20250263678-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA RNASE1, POLRMT, TERT POLB 82/4885P2RY2 4635/4885P2RY4 4783/4885
US-12559748-B2 Compositions and methods for the treatment of hemoglobinopathies HBZ, HBB, HBG1 POLB 796/4885P2RY2 4325/4885P2RY4 4394/4885
US-20260022377-A1 POLYNUCLEOTIDE COMPOSITIONS AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASES PRNP, UPF1, FUS POLB 387/4885P2RY2 1969/4885P2RY4 1893/4885
US-20230099822-A1 MR1 LIGANDS AND PHARMACEUTICAL COMPOSITIONS FOR IMMUNOMODULATION MRGPRX1, MRGPRX2, CD47 POLB 1956/4885P2RY2 618/4885P2RY4 716/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.