Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4826028 | 0.90 | KDM4E (0.50) | MAPK1NPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL3808604 | 0.88 | KDM4E (0.42) | MAPK1NPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL3641920 | 0.86 | KDM4E (0.44) | MAPK1NPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL9423136 | 0.86 | ALDH1A1 (0.56) | MAPK1NPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL18435335 | 0.86 | MAPK1 (0.41) | MAPK1NPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL13728897 | 0.86 | MAPT (0.43) | MAPK1NPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL14820212 | 0.83 | MAPK1 (0.42) | MAPK1NPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL14653302 | 0.82 | SMN1; SMN2 (0.49) | MAPK1NPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL10479256 | 0.82 | MAPK1 (0.47) | MAPK1NPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL3804631 | 0.82 | PDE2A (0.53) | MAPK1NPSR1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185537-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | Pfizer Inc. (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009016498-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |