Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1072192 | 0.95 | CYP2C19 (0.39) | CYP2C19HIF1ASMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL19510269 | 0.95 | CYP2C19 (0.39) | CYP2C19HIF1ASMN1; SMN2ALDH1A1KDM4E | |
| Iodide SCHEMBL1054412 | 0.81 | HIF1A (0.50) | CYP2C19HIF1ASMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL477383 | 0.76 | HIF1A (0.50) | CYP2C19HIF1ASMN1; SMN2ALDH1A1KDM4E | |
| Bromide SCHEMBL161017 | 0.76 | HIF1A (0.50) | CYP2C19HIF1ASMN1; SMN2ALDH1A1KDM4E | |
| Water SCHEMBL3422252 | 0.76 | HIF1A (0.50) | CYP2C19HIF1ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL3961571 | 0.74 | CYP2C19 (0.38) | CYP2C19HIF1ASMN1; SMN2ALDH1A1KDM4E | |
| Perchlorate SCHEMBL11848103 | 0.71 | HIF1A (0.44) | CYP2C19HIF1ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL9180560 | 0.71 | HIF1A (0.44) | CYP2C19HIF1ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8972925 | 0.71 | HIF1A (0.44) | CYP2C19HIF1ASMN1; SMN2ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8604201-B2 | Use of cyclovinyl phosphine/copper complexes as arylation catalysts | CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2013-12-10 | — | — | US | disclosed |
| US-20100298569-A1 | USE OF CYCLOVINYL PHOSPHINE/COPPER COMPLEXES AS ARYLATION CATALYSTS | CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298569-A1 | USE OF CYCLOVINYL PHOSPHINE/COPPER COMPLEXES AS ARYLATION CATALYSTS | CPNE4, CBR3, DDT | CYP2C19 873/4885HIF1A 3981/4885SMN1; SMN2 4303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.