Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 15/20 | 0.60 |
| ▸ | F2 | P00734 | 14/20 | 0.60 |
| ▸ | F7 | P08709 | 9/20 | 0.49 |
| ▸ | F10 | P00742 | 8/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 8/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 8/20 | 0.49 |
| ▸ | F12 | P00748 | 3/20 | 0.49 |
| ▸ | F9 | P00740 | 1/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27903245 | 1.00 | F11 (0.60) | F11F2F7F10PRSS1 | |
| Hydrochloric Acid SCHEMBL27754452 | 0.99 | F11 (0.59) | F11F2F7F10PRSS1 | |
| Hydrochloric Acid SCHEMBL3761016 | 0.99 | F11 (0.59) | F11F2F7F10PRSS1 | |
| SCHEMBL6436777 | 0.91 | F11 (0.61) | F11F2F7F10PRSS1 | |
| SCHEMBL13054338 | 0.90 | F11 (0.56) | F11F2F7F10PRSS1 | |
| SCHEMBL27775086 | 0.90 | F11 (0.56) | F11F2F7F10PRSS1 | |
| SCHEMBL3759667 | 0.90 | F11 (0.56) | F11F2F7F10PRSS1 | |
| Hydrochloric Acid SCHEMBL3765641 | 0.90 | F11 (0.56) | F11F2F7F10PRSS1 | |
| Hydrochloric Acid SCHEMBL3763597 | 0.89 | F11 (0.55) | F11F2F7F10PRSS1 | |
| SCHEMBL28782638 | 0.88 | F7 (0.47) | F11F2F7F10KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299091-B2 | Aminoisoquinoline thrombin inhibitor with improved bioavailability | MSD OSS B.V. (NL) | 2012-10-30 | — | — | US | claimed |
| US-20100305153-A1 | AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | N.V. ORGANON | 2010-12-02 | — | — | US | claimed |
| EP-2054402-A1 | AN AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | N.V. Organon (NL) | 2009-05-06 | — | — | EP | claimed |
| WO-2008017650-A1 | AN AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | N.V. ORGANON (NL) | 2008-02-14 | — | — | WO | claimed |
| US-8299091-B2 | Aminoisoquinoline thrombin inhibitor with improved bioavailability | MSD OSS B.V. (NL) | 2012-10-30 | — | — | US | disclosed |
| US-8299091-B2 | Aminoisoquinoline thrombin inhibitor with improved bioavailability | MSD OSS B.V. (NL) | 2012-10-30 | — | — | US | disclosed |
| US-20100305153-A1 | AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | N.V. ORGANON | 2010-12-02 | — | — | US | disclosed |
| US-20100305153-A1 | AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | N.V. ORGANON | 2010-12-02 | — | — | US | disclosed |
| EP-2054402-A1 | AN AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | N.V. Organon (NL) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008017650-A1 | AN AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | N.V. ORGANON (NL) | 2008-02-14 | — | — | WO | disclosed |
| WO-2008017650-A1 | AN AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | N.V. ORGANON (NL) | 2008-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305153-A1 | AMINOISOQUINOLINE THROMBIN INHIBITOR WITH IMPROVED BIOAVAILABILITY | TFPI, TFPI2, PREP | F11 152/4885F2 7/4885F7 564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.