Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.94 |
| ▸ | LMNA | P02545 | 7/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.68 |
| ▸ | HPGD | P15428 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 3/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | CASP3 | P42574 | 1/20 | 0.68 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.68 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | POLB | P06746 | 4/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CASP1 | P29466 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3749766 | 0.99 | ALDH1A1 (0.92) | ALDH1A1LMNAKDM4ESMN1; SMN2HPGD | |
| SCHEMBL3749453 | 0.97 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2948940 | 0.84 | ALDH1A1 (0.68) | ALDH1A1LMNAKDM4ESMN1; SMN2HPGD | |
| SCHEMBL17909964 | 0.82 | ALDH1A1 (0.66) | ALDH1A1LMNAKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2919879 | 0.76 | ALDH1A1 (0.75) | ALDH1A1LMNAKDM4ESMN1; SMN2HPGD | |
| SCHEMBL13407763 | 0.72 | KMT2A (1.00) | ALDH1A1LMNAKDM4ESMN1; SMN2HPGD | |
| SCHEMBL1101960 | 0.71 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2952156 | 0.71 | ALDH1A1 (0.70) | ALDH1A1LMNAKDM4ESMN1; SMN2HPGD | |
| SCHEMBL3754226 | 0.71 | GAK (0.67) | ALDH1A1LMNAKDM4ESMN1; SMN2HPGD | |
| SCHEMBL2947859 | 0.71 | SMN1; SMN2 (1.00) | ALDH1A1LMNAKDM4ESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962639-B2 | Potassium channel modulators | ABBVIE INC. (US) | 2015-02-24 | — | — | US | disclosed |
| WO-2010138828-A2 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |
| US-20100305109-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305109-A1 | POTASSIUM CHANNEL MODULATORS | KCNQ1, KCNQ2, KCNJ2 | ALDH1A1 1031/4885LMNA 741/4885KDM4E 680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.