SCHEMBL3755880

SCHEMBL3755880

CC(=O)NC[C@H]1CN(c2ccc(-n3cnc(CO)c3)c(F)c2)C(=O)O1

nearest known ligand 0.65

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.65
MAOB P27338 5/20 0.65
PTGS1 P23219 2/20 0.65
SDHA P31040 2/20 0.65
LMNA P02545 1/20 0.65
CALML3 P27482 1/20 0.65
F10 P00742 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3754635 1.00 MAOA (0.65) MAOAMAOBPTGS1SDHALMNA
SCHEMBL7838545 0.94 MAOA (0.64) MAOAMAOBPTGS1SDHALMNA
SCHEMBL7838549 0.94 MAOA (0.64) MAOAMAOBPTGS1SDHALMNA
SCHEMBL7842942 0.93 MAOA (0.65) MAOAMAOBPTGS1SDHALMNA
SCHEMBL7842939 0.93 MAOA (0.65) MAOAMAOBPTGS1SDHALMNA
SCHEMBL8124484 0.92 MAOA (0.64) MAOAMAOBPTGS1SDHALMNA
SCHEMBL7651821 0.92 MAOA (0.64) MAOAMAOBPTGS1SDHALMNA
SCHEMBL4017727 0.90 MAOA (0.66) MAOAMAOBPTGS1SDHALMNA
SCHEMBL3754677 0.90 MAOA (0.61) MAOAMAOBPTGS1SDHALMNA
SCHEMBL13054904 0.90 MAOA (0.61) MAOAMAOBPTGS1SDHALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100298384-A1 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LTD. (IN) 2010-11-25 US disclosed
US-20100298384-A1 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LTD. (IN) 2010-11-25 US disclosed
US-20100298384-A1 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LTD. (IN) 2010-11-25 US disclosed
WO-2008143649-A2 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LIMITED (IN) 2008-11-27 WO disclosed
US-6495551-B1 P-IMIDAZOLE-PHENYL-OXAZOLIDINES; EFFECTIVE AGAINST GRAMPOSITIVE BACTERIA SYNGENTA LIMITED (GB) 2002-12-17 US disclosed
EP-0807112-B1 HETERO-AROMATIC RING SUBSTITUTED PHENYLOXAZOLIDINONE ANTIMICROBIALS UPJOHN CO (US) 2001-09-05 EP disclosed
US-6194441-B1 GRAMNEGATIVE AND GRAMPOSITIVE BACTERIA ZENECA LTD. (GB) 2001-02-27 US disclosed
US-6124334-A A BACTERICIDE TREATING INFECTIONS CAUSED BY GRAM-POSITIVE AEROBIC BACTERIA SUCH AS STAPHYLOCOCCUS, STREPTOCOCCUS AND ENTEROCOCCUS AS WELL AS ANAEROBIC ORGANISMS SUCH AS BACTEROIDES AND CLOSTRIDIUM AND MYCOBACTERIDIUM PHARMACIA & UPJOHN COMPANY (US) 2000-09-26 US disclosed
EP-1034175-A1 SUBSTITUTED PHENYLOXAZOLIDINONES AND THEIR USE AS ANTIBIOTICS AstraZeneca UK Limited (GB) 2000-09-13 EP disclosed
WO-1999028317-A1 SUBSTITUTED PHENYLOXAZOLIDINONES AND THEIR USE AS ANTIBIOTICS ASTRAZENECA UK LIMITED (GB) 1999-06-10 WO disclosed
EP-0807112-A1 HETERO-AROMATIC RING SUBSTITUTED PHENYLOXAZOLIDINONE ANTIMICROBIALS PHARMACIA & UPJOHN COMPANY (US) 1997-11-19 EP disclosed
WO-1997031917-A9 SUBSTITUTED PHENYLOXAZOLIDINONES AND THEIR USE AS ANTIBIOTICS 1997-10-30 WO disclosed
WO-1996023788-A1 HETERO-AROMATIC RING SUBSTITUTED PHENYLOXAZOLIDINONE ANTIMICROBIALS PHARMACIA + UPJOHN COMPANY (US) 1996-08-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100298384-A1 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS OXA1L, MIF, VIP MAOA 3034/4885MAOB 2709/4885PTGS1 362/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.